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Table 7 Comparison of clinical outcomes between the control and FCP subgroups in couples undergoing ICSIa

From: Diverse impacts of female chromosomal polymorphisms on assisted reproduction outcomes: a retrospective cohort study

 

Rate (cases/study subjects (%))

RR (95% CI)

P value

Biochemical pregnancy

Control

1080/2919(37.0)

Ref.

Ref.

qh+

34/101(33.7)

0.91(0.69 ~ 1.20)

0.505

pstk+

29/80(36.3)

0.98(0.73 ~ 1.32)

0.892

inv(9)

13/38(34.2)

0.93(0.59 ~ 1.44)

0.729

multiple

12/25(48.0)

1.30(0.86 ~ 1.96)

0.214

others

10/20(50.0)

1.35(0.87 ~ 2.10)

0.181

Clinical pregnancy

Control

901/2919(30.9)

Ref.

Ref.

qh+

26/101(25.7)

0.83(0.60 ~ 1.17)

0.289

pstk+

25/80(31.3)

1.01(0.73 ~ 1.41)

0.941

inv(9)

9/38(23.7)

0.77(0.43 ~ 1.36)

0.365

multiple

10/25(40.0)

1.30(0.80 ~ 2.10)

0.293

others

7/20(35.0)

1.13(0.62 ~ 2.07)

0.681

Miscarriage

Control

307/901(34.1)

Ref.

Ref.

qh+

4/26(15.4)

0.45(0.18 ~ 1.12)

0.085

pstk+

11/25(44.0)

1.29(0.82 ~ 2.03)

0.267

inv(9)

3/9(33.3)

0.98(0.39 ~ 2.48)

0.963

multiple

1/10(10.0)

0.29(0.05 ~ 1.89)

0.197

others

0/7(0.0)

/

0.999

Preterm birth

Control

86/560(15.4)

Ref.

Ref.

qh+

3/20(15.0)

0.98(0.34 ~ 2.82)

0.965

pstk+

4/11(36.4)

2.37(1.06 ~ 5.30)

0.036

inv(9)

0/6(0.0)

NA

NA

multiple

0/8(0.0)

NA

NA

others

0/7(0.0)

NA

NA

Live birth

Control

558/2906(19.2)

Ref.

Ref.

qh+

20/101(19.8)

1.03(0.69 ~ 1.54)

0.880

pstk+

11/80(13.8)

0.72(0.41 ~ 1.25)

0.237

inv(9)

6/38(15.8)

0.82(0.39 ~ 1.72)

0.603

multiple

8/24(33.3)

1.74(0.98 ~ 3.07)

0.058

others

7/20(35.0)

1.82(1.00 ~ 3.33)

0.051

  1. aThe number of couples at each stage was depicted in Fig. S3, while the methods employed for calculation were elucidated in the Materials and Methods Section. Couples who were lost to follow-up were excluded from the calculation of the live birth rate
  2. FCP female chromosomal polymorphism, aRR adjusted risk ratio, CI confidence interval, Ref reference, NA not applicable
  3. Log-binomial regression models were employed to calculate the aRRs with their corresponding 95% CIs and P values
  4. P values less than 0.050 were shown in bold