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Table 5 Comparison of clinical outcomes between the control and FCP subgroups in couples undergoing IVFa

From: Diverse impacts of female chromosomal polymorphisms on assisted reproduction outcomes: a retrospective cohort study

 

Rate (cases/study subjects (%))

aRR (95% CI)

Adjusted P value

Biochemical pregnancy

Control

2381/6379(37.3)

Ref.

Ref.

qh+

91/211(43.1)

1.15(0.98 ~ 1.34)

0.088

pstk+

69/189(36.5)

0.98(0.81 ~ 1.18)

0.802

inv(9)

26/62(41.9)

1.13(0.84 ~ 1.52)

0.412

multiple

22/53(41.5)

1.10(0.80 ~ 1.52)

0.548

others

23/54(42.6)

1.14(0.83 ~ 1.55)

0.426

Clinical pregnancy

Control

1960/6379(30.7)

Ref.

Ref.

qh+

78/211(37.0)

1.20(1.00 ~ 1.44)

0.048

pstk+

58/189(30.7)

1.00(0.80 ~ 1.24)

0.992

inv(9)

24/62(38.7)

1.27(0.92 ~ 1.74)

0.143

multiple

16/53(30.2)

0.98(0.65 ~ 1.48)

0.914

others

22/54(40.7)

1.32(0.96 ~ 1.83)

0.090

Miscarriage

Control

644/1960(32.9)

Ref.

Ref.

qh+

21/78(26.9)

0.82(0.57 ~ 1.19)

0.298

pstk+

17/58(29.3)

0.89(0.60 ~ 1.34)

0.586

inv(9)

9/24(37.5)

1.14(0.68 ~ 1.92)

0.626

multiple

7/16(43.8)

1.34(0.76 ~ 2.34)

0.312

others

7/22(31.8)

0.97(0.52 ~ 1.79)

0.916

Preterm birth

Control

205/1212(16.9)

Ref.

Ref.

qh+

9/57(15.8)

0.94(0.51 ~ 1.74)

0.848

pstk+

6/39(15.4)

0.92(0.44 ~ 1.94)

0.821

inv(9)

1/14(7.1)

0.42(0.06 ~ 2.78)

0.368

multiple

5/8(62.5)

3.71(2.14 ~ 6.43)

< 0.001

others

2/12(16.7)

0.98(0.28 ~ 3.49)

0.975

Live birth

Control

1209/6362(19.0)

Ref.

Ref.

qh+

57/211(27.0)

1.42(1.13 ~ 1.78)

0.003

pstk+

38/189(20.1)

1.06(0.79 ~ 1.41)

0.704

inv(9)

14/62(22.6)

1.19(0.75 ~ 1.90)

0.458

multiple

8/53(15.1)

0.79(0.42 ~ 1.50)

0.467

others

12/53(22.6)

1.19(0.72 ~ 1.96)

0.494

  1. aThe number of couples at each stage was depicted in Fig. S2, while the methods employed for calculation were elucidated in the Materials and Methods Section. Couples who were lost to follow-up were excluded from the calculation of the live birth rate
  2. FCP female chromosomal polymorphism, aRR adjusted risk ratio, CI confidence interval, Ref reference
  3. Log-binomial regression models with adjustment for paternal factor were employed to calculate the aRRs with their corresponding 95% CIs and adjusted P values
  4. P values less than 0.050 were shown in bold