Total (N = 637) | Any Progesterone (N = 348) | ap-value | 17-OHPC (N = 296) | bp-value | Vaginal Progesterone (N = 42) | cp-value | No treatment (N = 287) | |
---|---|---|---|---|---|---|---|---|
Demographic factors and reproductive history before the index pregnancy | ||||||||
Age | 30.8 ± 6.0 | 31.0 ± 6.0 | 0.17 | 31.0 ± 6.1 | 0.25 | 30.7 ± 5.2 | 0.5 | 30.5 ± 5.9 |
Gravida | 4 (3–5) | 4 (3–5) | 0.012 | 4 (3–5) | < .001 | 4 (3–5) | 0.615 | 4 (3–6) |
Parity | 2 (1–3) | 2 (1–3) | < .001 | 2 (1–2) | < .001 | 2 (1–3) | 0.0441 | 2 (1–3) |
dRace/Ethnicity | e0.89 | e0.73 | e0.49 | |||||
Non-Hispanic White | 29 (4.6) | 16 (4.6) | 11 (3.7) | 4 (9.5) | 14 (4.6) | |||
Non-Hispanic Black | 75 (11.8) | 41 (11.8) | 34 (11.4) | 6 (14.3) | 34 (11.8) | |||
Hispanic/Latina | 460 (72.2) | 258 (74.1) | 223 (75.0) | 28 (66.7) | 201 (69.8) | |||
Asian/Pacific Islander | 13 (2.0) | 8 (2.3) | 8 (2.7) | 0 (0) | 5 (1.7) | |||
Other | 50 (7.8) | 23 (6.6) | 19 (6.4) | 3 (7.1) | 27 (9.4) | |||
BMI | 31.9 ± 7.1 | 32.1 ± 7.6 | 0.5 | 32.3 ± 7.7 | 0.36 | 30.1 ± 6.8 | 0.76 | 31.5 ± 6.4 |
Term delivery number | 1 (0–2) | 1 (0–1) | < .001 | 1 (0–1) | < .001 | 1 (0–2) | 0.367 | 1 (0–2) |
Preterm delivery number | 1 (1–2) | 1 (1–2) | 0.829 | 1 (1–2) | 0.798 | 1 (1–2) | 0.808 | 1 (1–2) |
Demonstrated and Proposed Risk Factors for sPTB | ||||||||
Total Maternal weight gain | 10.7 ± 6.4 | 10.4 ± 6.3 | 0.67 | 10.7 ± 6.6 | 0.65 | 9.1 ± 4.5 | 0.82 | 11.2 ± 6.7 |
Gestational age of earliest sPTB | 32 (27–35) | 32 (25–35) | < .001 | 32 (26–34) | < .001 | 32 (27–35) | 0.044 | 34 (30–36) |
Number of spontaneous preterm births 1 | 498 (78.2) | 275 (79.0) | 234 (78.8) | 35 (83.3) | 222 (77.1) | |||
2 | 102 (16.0) | 53 (15.2) | 44 (14.8) | 6 (14.3) | 49 (17.0) | |||
3 or more | 37 (5.8) | 20 (5.7) | 0.89 | 19 (6.4) | 0.89 | 1 (2.4) | 0.93 | 17 (5.9) |
Chronic Hypertension | 53 (8.3) | 29 (8.3) | 0.47 | 26 (8.6) | 0.63 | 3 (7.1) | 0.63 | 24 (8.3) |
Pregestational Diabetes | 50 (7.8) | 34 (9.8) | 0.026 | 31 (10.4) | 0.034 | 2 (4.8) | 0.2 | 16 (5.6) |
Short Cervix | 74 (11.6) | 59 (17.0) | < .001 | 45 (15.2) | < .001 | 10 (23.8) | 0.001 | 15 (5.2) |
Tobacco Use | 42 (6.6) | 15 (4.3) | 0.055 | 14 (4.7) | 0.054 | 1 (2.4) | 0.89 | 27 (9.4) |
Alcohol Use | 7 (1.1) | 4 (1.1) | 1 | 3 (1.0) | 1 | 0 (0) | 1 | 3 (1.0) |
Illicit Substance Use | 67 (10.5) | 32 (9.2) | 0.094 | 29 (9.8) | 0.17 | 3 (7.1) | 0.4 | 35 (12.2) |
Short inter-pregnancy interval | 76 (11.9) | 43 (12.4) | 0.92 | 37 (12.5) | 0.94 | 4 (9.5) | 0.79 | 33 (11.5) |
UTI | 155 (24.3) | 103 (27.0) | 0.25 | 75 (25.3) | 0.45 | 14 (33.3) | 0.17 | 62 (21.5) |
STI | 60 (9.4) | 32 (9.2) | 0.69 | 26 (8.8) | 0.61 | 6 (14.3) | 0.71 | 28 (9.7) |
BV | 91 (14.3) | 63 (18.1) | 0.002 | 53 (17.8) | 0.007 | 8 (19.0) | 0.016 | 28 (9.7) |
Antepartum vaginal bleeding | 43 (6.8) | 26 (7.5) | 0.69 | 23 (7.7) | 0.7 | 2 (4.8) | 1 | 17 (5.9) |
Prior LEEP or CKC | 7 (1.1) | 2 (0.6) | 0.43 | 2 (0.7) | 0.36 | 1 (2.4) | 1 | 5 (1.7) |
History of uterine instrumentation | 93 (14.6) | 58 (16.7) | 0.17 | 48 (16.2) | 0.24 | 8 (19.0) | 0.28 | 35 (12.2) |
Periodontal Disease | 5 (0.8) | 2 (0.6) | 1 | 1 (0.3) | 0.56 | 1 (2.4) | 0.35 | 3 (1.0) |
Limited prenatal care (< 5 visits) | 83 (13.0) | 11 (3.2) | < .001 | 8 (2.7) | < .001 | 2 (4.8) | 0.011 | 72 (25.0) |
Gestational Diabetes | 67 (10.5) | 43 (12.4) | 0.26 | 35 (11.8) | 0.42 | 6 (14.3) | 0.28 | 24 (8.3) |