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Table 3 Main factors affecting non- live birth outcomes

From: Comparison of pregnancy outcomes among patients of different ages who underwent frozen-thawed high-quality single blastocyst transfer

Factors

Univariable

Multivariable

OR (95% CI)

P value

OR (95% CI)

P value

Infertility duration (year)

< 3

Ref

   

≥ 3

1.282(1.029–1.597)

0.027*

1.408(1.049–1.889)

0.023*

BMI(kg/m2)

< 18.5

Ref

   

18.5 ≤ BMI < 24

1.347(0.968–1.874)

0.077

1.235(0.882–1.730)

0.219

24 ≤ BMI < 28

1.460(0.974–2.187)

0.067

1.361(0.900-2.057)

0.144

≥ 28

1.831(1.007–3.330)

0.047*

1.773(0.967–3.252)

0.064

Female age(year)

< 30

Ref

   

30 ≤ Age < 35

0.992(0.771–1.276)

0.948

1.175(0.845–1.633)

0.337

35 ≤ Age ≤ 37

1.382(0.967–1.975)

0.076

1.517(0.944–2.439)

0.085

37< Age ≤ 40

1.997(1.359–2.934)

< 0.001*

2.121(1.233–3.647)

0.007*

Male age(year)

< 30

Ref

   

30 ≤ Age < 35

0.941(0.695–1.275)

0.696

0.909(0.649–1.273)

0.578

35 ≤ Age < 40

1.219(0.878–1.693)

0.236

0.930(0.609–1.419)

0.736

≥ 40

1.530(1.012–2.312)

0.044*

0.992(0.572–1.720)

0.977

Infertility type

Primary infertility

Ref

   

Secondary infertiliy

1.271(1.015–1.592)

0.037*

0.246(0.024–2.474)

0.234

Transplant cycle

First cycle

Ref

   

Second cycle

1.365(1.078–1.729)

0.010*

0.772(0.605–0.986)

0.038*

PCOS

No

Ref

   

Yes

1.029(0.783–1.352)

0.839

  

Endometriosis

No

Ref

   

Yes

0.868(0.459–1.642)

0.663

  

Diabetes

No

Ref

   

Yes

0.687(0.153–3.081)

0.624

  

Hypertension

No

Ref

   

Yes

0.917(0.294–2.858)

0.881

  

Thyroid disease

No

Ref

   

Yes

0.638(0.242–1.688)

0.366

  

Number of births

0

Ref

   

1–2

1.302(1.026–1.651)

0.030*

1.275(0.857–1.897)

0.232

≥ 3

1.497(0.249–9.001)

0.660

1.419(0.204–9.859)

0.723

Number of miscarriages

0

Ref

   

1–2

1.332(1.053–1.683)

0.017*

1.709(1.057–2.763)

0.029*

≥ 3

1.304(0.895–1.899)

0.167

1.530(0.655–3.573)

0.326

Number of pregnancies

0

Ref

   

1–2

1.192(0.937–1.517)

0.153

0.158(0.015–1.637)

0.122

≥ 3

1.436(1.040–1.983)

0.028*

0.158(0.013–1.843)

0.141

Number of early spontaneous abortion

0

Ref

   

1

1.106(0.810–1.509)

0.527

  

2

1.280(0.774–2.117)

0.337

  

Male smoking history

No

Ref

   

Yes

1.334(0.997–1.786)

0.053

  

Endometrial thickness (mm)

< 8

Ref

   

8–12

0.815(0.599–1.107)

0.191

  

> 12

0.916(0.486–1.726)

0.785

  
  1. BMI Body Mass Index, PCOS Polycystic Ovary Syndrome
  2. *P < 0.05 was statistical significance