Impact of thyroid autoimmunity on the cumulative live birth rates after IVF/ICSI treatment cycles

Table 2 Protocols for controlled ovarian stimulation and data on IVF and first embryo transfer cycle

Characteristics	TAI group N = 2603	Control group N = 10,193	P-value
Protocols for COS, No. (%)
Ultralong GnRH agonist	296 (11.4)	1142 (11.2)	0.304
Long GnRH agonist	458 (17.6)	1928 (18.9)
GnRH antagonist	1849 (71.0)	7123 (69.9)
Duration of stimulation, median (IQR), days	11.0 (9.0–12.0)	11.0 (9.0–12.0)	0.683
Total dose of gonadotropin, median (IQR), IU	2437.5 (1800.0-3300.0)	2475.0 (1800.0-3275.0)	0.929
LH level on day of trigger, median (IQR), mIU/mL	1.2 (0.6–2.3)	1.2 (0.6–2.5)	0.176
Oestradiol level on day of trigger, median (IQR), mIU/mL	7986.0 (5191.0-12032.0)	7637.5 (5037.0-11831.3)	0.015
Progesterone level on day of trigger, median (IQR), mIU/mL	2.0 (1.4-3.0)	2.0 (1.4-3.0)	0.545
Number of oocytes retrieved, median (IQR)	11.0 (7.0–17.0)	11.0 (7.0–17.0)	0.718
Fertilization per oocyte inseminated or injected, median (IQR), % ^a	0.7 (0.5–0.8)	0.7 (0.5–0.8)	0.967
Fertilization No. (%)
IVF	1933 (74.3)	7773 (76.3)	0.034
ICSI	670 (25.7)	2420 (23.7)	0.034
Number of good-quality embryos, median (IQR) ^b	5.0 (2.0–8.0)	5.0 (2.0–8.0)	0.812

GnRH: gonadotropin-releasing hormone; LH: luteinizing hormone; COS: controlled ovarian stimulation; IQR: interquartile range; SD: standard deviation
^a Normal fertilization was defined as the number of zygotes with two pronuclei. In the IVF group, the denominator was the number of retrieved oocytes. In the ICSI group, the number of metaphase II oocytes was the denominator
^b Embryos were evaluated on the third day after fertilization. Good-quality embryos were developed from two-pronuclei zygotes and met the following criteria: (1) more than five blastomeres, (2) size difference of less than 20%, and (3) fragmentation of less than 50%

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