Table 3 Crude and adjusted odds ratios of adverse perinatal outcomes according to COVID-19 vaccination doses

Preterm birth

unvaccinated

112,003

9,151(8.17)

Baseline

1 dose

6,774

589(8.70)

1.07(0.98 to 1.16)

0.12

1.00(0.91 to 1.10)

0.89

2 doses

10,711

807(7.53)

0.91(0.84 to 0.98)

0.02

0.85(0.79 to 0.92)

<0.001

Extremely preterm birth

unvaccinated

112,003

1,497(1.34)

Baseline

1 dose

6,774

70(1.03)

0.77(0.60 to 0.98)

0.03

0.73(0.56 to 0.95)

0.01

2 doses

10,711

63(0.59)

0.43(0.33 to 0.56)

<0.001

0.43(0.33 to 0.56)

<0.001

Congenital anomaly

unvaccinated

112,003

382(0.34)

Baseline

1 dose

6,774

19(0.28)

0.82(0.51 to 1.30)

0.40

0.76(0.46 to 1.24)

0.27

2 doses

10,711

45(0.42)

1.23(0.90 to 1.68)

0.18

1.16(0.84 to 1.61)

0.35

stillbirth

unvaccinated

112,003

815(0.73)

Baseline

1 dose

6,774

45(0.66)

0.91(0.67 to 1.23)

0.55

0.74(0.53 to 1.04)

0.08

2 doses

10,711

45(0.42)

0.57(0.42 to 0.77)

<0.001

0.50(0.36 to 0.70)

<0.001

Intrauterine growth restriction

unvaccinated

112,003

2,169(1.94)

Baseline

1 dose

6,774

135(1.99)

1.02(0.86 to 1.22)

0.74

`.07 (0.88 to 1.29)

0.47

2 doses

10,711

212(1.98)

1.02(0.88 to 1.17)

0.75

1.03(0.88 to 1.20)

0.64

Low birth weight

unvaccinated

112,003

7,007(6.26)

Baseline

1 dose

6,774

416(6.14)

0.98(0.88 to 1.08)

0.70

0.99(0.86 to 1.14)

0.92

2 doses

10,711

601(5,61)

0.89(0.81 to 0.97)

0.008

1.08(0.97 to 1.21)

0.13

Very low birth weight

unvaccinated

112,003

1,468(1.31)

Baseline

1 dose

6,774

73(1.08)

0.82(0.64 to 1.03)

0.10

1.04(0.69 to 1.57)

0.84

2 doses

10,711

72(0.67)

0.50(0.40 to 0.64)

<0.001

0.99(0.69 to 1.43)

0.99

NICU admission

unvaccinated

112,003

11,347(10.13)

Baseline

1 dose

6,774

725(10.70)

1.06(0.98 to 1.15)

0.13

1.02(0.93 to 1.11)

0.65

2 doses

10,711

1,037(9.68)

0.95(0.88 to 1.01)

0.14

0.99(0.92 to 1.07)

0.98

Low 5-minute Apgar score

unvaccinated

112,003

1,341(1.20)

Baseline

1 dose

6,774

69(1.02)

0.84(0.66 to 1.08)

0.18

0.87(0.62 to 1.24)

0.46

2 doses

10,711

84(0.78)

0.65(0.52 to 0.81)

<0.001

1.06(0.80 to 1.40)

0.67

Neonatal death

unvaccinated

112,003

146(0.13)

Baseline

1 dose

6,774

5(0.07)

0,56(0.23 to 1.38)

0.21

0.62(0.22 to 1.74)

0.36

2 doses

10,711

10(0.09)

0.71(0.37 to 1.35)

0.30

1.40(0.76 to 2.94)

0.24