Table 2 Crude and adjusted odds ratios of adverse perinatal outcomes according to COVID-19 vaccination

Preterm birth

unvaccinated

112,003

9,151(8.17)

Baseline

vaccinated

17,485

1,396(7.98)

0.97(0.91 to 1.03)

0.40

0.91(0.85 to 0.97)

0.006

Extremely preterm birth

unvaccinated

112,003

1,497(1.34)

Baseline

vaccinated

17,485

133(0.76)

0.56(0.47 to 0.67)

<0.001

0.55(0.45 to 0.66)

<0.001

Congenital anomaly

unvaccinated

112,003

382(0.34)

Baseline

vaccinated

17,485

64(0.37)

1.07(0.82 to 1.39)

0.60

1.01(0.76 to 1.33)

0.94

Stillbirth

unvaccinated

112,003

815(0.73)

Baseline

vaccinated

17,485

90(0.51)

0.70(0.56 to 0.87)

0.002

0.60(0.47 to 0.76)

<0.001

Intrauterine growth restriction

unvaccinated

112,003

2,169(1.94)

Baseline

vaccinated

17,485

347(1.98)

.02(0.91 to 1.14)

0.66

1.04 (0.92 to 1.18)

0.44

Low birth weight

unvaccinated

112,003

7,007(6.2)

Baseline

vaccinated

17,485

1,017(5.8)

0.92(0.86 to 0.99)

0.02

1.05(0.96 to 1.14)

0.27

Very low birth weight

unvaccinated

112,003

1,468(1.3)

Baseline

vaccinated

17,485

145(0.8)

0.62(0.53 to 0.74)

<0.001

1.01(0.76 to 1.34)

0.90

NICU admission

unvaccinated

112,003

11,347(10.1)

Baseline

vaccinated

17,485

1,762(10.0)

0.99(0.94 to 1.04)

0.82

1.00(0.94 to 1.06)

0.80

Low 5-minute Apgar score

unvaccinated

112,003

1,341(1.2)

Baseline

vaccinated

17,485

153(0.8)

0.72(0.61 to 0.86)

<0.001

0.98(0.78 to 1.23)

0.88

Neonatal death

unvaccinated

112,003

146(0.13)

Baseline

vaccinated

17,485

15(0.09)

0,65(0.38 to 1.11)

0.12

1.07(0.60 to 1.91)

0.80