Table 2 The pooled results of meta-analysis and subgroup analyses for main and secondary outcomes of D-LAH and T-LAH
From: Two laser-assisted hatching methods of embryos in ART: a systematic review and meta-analysis
Group | No. of studies | No. of Events/Total | Effect size (RR 95%Cl) | P | I2(%) |
|---|---|---|---|---|---|
Clinical pregnancy | 9 | D-LAH:1144/2405 T-LAH:853/2239 | 0.93(0.79–1.10) | 0.41 | 71 |
Fresh embryo clinical pregnancy | 5 | D-LAH:144/672 T-LAH:250/1093 | 0.83(0.56–1.23) | 0.36 | 74 |
Fresh embryo clinical pregnancy | 4 | D-LAH:1000/1733 T-LAH:603/1146 | 0.97(0.81–1.16) | 0.71 | 74 |
RCT clinical pregnancy | 4 | D-LAH:79/240 T-LAH:81/241 | 0.98(0.72–1.33) | 0.90 | 42 |
Non-RCT clinical pregnancy | 5 | D-LAH:1065/2165 T-LAH:772/1998 | 0.91(0.73–1.12) | 0.36 | 83 |
Implantation rate | 6 | D-LAH:1286/3740 T-LAH:1038/3872 | 1.02(0.80–1.28) | 0.89 | 89 |
Singleton pregnancy | 2 | D-LAH:669/1082 T-LAH:83/445 | 2.28(1.08–4.82) | 0.03 | 89 |
Multiple pregnancy | 6 | D-LAH:145/1216 T-LAH:149/1376 | 1.25(0.78–2.00) | 0.36 | 41 |
Ongoing pregnancy | 4 | D-LAH:122/406 T-LAH:89/383 | 1.25(0.89–1.77) | 0.20 | 54 |
Miscarriages | 5 | D-LAH:66/473 T-LAH:106/583 | 0.77(0.58–1.03) | 0.07 | 0 |
Preterm birth | 2 | D-LAH:84/779 T-LAH:84/802 | 0.92(0.46–1.84) | 0.82 | 26 |
Live birth | 3 | D-LAH:822/1870 T-LAH:539/1562 | 0.93(0.79–1.09) | 0.37 | 63 |