PREDO, BMI-defined metabolome, SD units | ITU, BMI-related PMRS VIPa 0.7 SD units | ITU, BMI-related PMRS VIP 1.0 SD units | ITU, BMI-related PMRS VIP 1.2 SD units | ITU, BMI-related PMRS VIP 1.4 SD units | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR/MD | 95% CI | p | OR/MD | 95% CI | p | OR/MD | 95% CI | p | OR/MD | 95% CI | p | OR/MD | 95% CI | p | |
Maternal pregnancy compications | |||||||||||||||
GDM, yes vs. no | 2.33 | 1.49, 3.64 | 0.0002 | 1.65 | 1.27, 2.12 | 0.0001 | 1.70 | 1.29, 2.16 | < 0.0001 | 1.68 | 1.30, 2.18 | < 0.0001 | 1.65 | 1.27, 2.14 | 0.0001 |
Hypertensive pregnancy disorders | |||||||||||||||
Normotension | Ref | Ref | Ref | Ref | Ref | ||||||||||
Gestational hypertension, yes vs. no | 1.96 | 1.05, 3.68 | 0.04 | 1.56 | 0.70, 3.48 | 0.28 | 1.51 | 0.68, 3.36 | 0.32 | 1.57 | 0.70, 3.49 | 0.27 | 1.72 | 0.78, 3.78 | 0.18 |
Preeclampsia, yes vs. no | 3.34 | 1.73, 6.43 | 0.0003 | 1.99 | 1.13, 3.50 | 0.02 | 1.99 | 1.13, 3.51 | 0.02 | 1.85 | 1.05, 3.25 | 0.03 | 1.88 | 1.07, 3.27 | 0.03 |
Chronic hypertension, yes vs. no | 2.65 | 1.50, 4.77 | 0.001 | 0.48 | 0.09, 2.64 | 0.40 | 0.48 | 0.09, 2.48 | 0.38 | 0.44 | 0.09, 2.17 | 0.32 | 0.44 | 0.09, 2.18 | 0.32 |
Gestational weight gain category | |||||||||||||||
Normal | Ref | Ref | Ref | Ref | Ref | ||||||||||
Inadequate, yes vs. no | 1.40 | 0.82, 2.40 | 0.21 | 0.88 | 0.68, 1.14 | 0.33 | 0.90 | 0.70, 1.16 | 0.42 | 0.90 | 0.69, 1.16 | 0.72 | 0.90 | 0.70, 1.16 | 0.41 |
Exessive, yes vs. no | 1.11 | 0.66, 1.87 | 0.68 | 1.04 | 0.83, 1.31 | 0.68 | 1.05 | 0.84, 1.32 | 0.66 | 1.02 | 0.82, 1.27 | 0.83 | 1.03 | 0.82, 1.30 | 0.78 |
Birth outcomes | |||||||||||||||
Caesarian section vs. vaginal delivery | 1.35 | 0.89, 2.05 | 0.16 | 1.16 | 0.91, 1.48 | 0.22 | 1.17 | 0.91, 1.49 | 0.22 | 1.19 | 0.94, 1.53 | 0.15 | 1.20 | 0.94, 1.53 | 0.14 |
Gestational age, weeks | -0.64 | -0.97, -0.32 | 0.0001 | -0.07 | -0.21, 0.08 | 0.37 | -0.07 | -0.21, 0.08 | 0.37 | -0.07 | -0.22, 0.07 | 0.32 | -0.08 | -0.22, 0.07 | 0.30 |
Preterm birth, yes vs. no | 2.21 | 1.22, 4.02 | 0.009 | 1.05 | 0.65, 1.73 | 0.82 | 1.01 | 0.62, 1.66 | 0.97 | 0.98 | 0.60, 1.61 | 0.94 | 1.05 | 0.62, 1.72 | 0.84 |
NICU treatment, yes vs. no | 1.75 | 1.11, 2.74 | 0.02 | 1.29 | 0.94, 1.78 | 0.12 | 1.26 | 0.91, 1.73 | 0.17 | 1.24 | 0.90, 1.72 | 0.18 | 1.30 | 0.94, 1.79 | 0.11 |
Birth weight, grams | 75.66 | 8.23, 143.09 | 0.03 | 21.94 | -15.25, 59.14 | 0.25 | 22.93 | -14.28, 60.14 | 0.23 | 17.98 | -19.51, 55.47 | 0.34 | 8.64 | -28.82, 46.10 | 0.65 |
Neurodevelopment | |||||||||||||||
Number of areas of child neurodevelopmental delayb | 2.28 | 1.52, 3.41 | < 0.0001 | 1.08 | 0.85, 1.37 | 0.54 | 1.07 | 0.84, 1.35 | 0.59 | 1.07 | 0.84, 1.36 | 0.57 | 1.06 | 0.84, 1.35 | 0.63 |
Bayley Scales of Infant and Toddler Development, raw units | |||||||||||||||
Language development | 0.09 | -0.21, 0.40 | 0.54 | 0.09 | -0.22, 0.39 | 0.58 | 0.08 | -0.23, 0.39 | 0.6 | 0.07 | -0.23, 0.38 | 0.64 | |||
Motor development | 0.16 | -0.24, 0.56 | 0.43 | 0.14 | -0.26, 0.54 | 0.49 | 0.10 | -0.30, 0.50 | 0.62 | 0.15 | -0.25, 0.55 | 0.46 | |||
Cognitive development | -0.13 | -0.29, 0.03 | 0.11 | -0.13 | -0.29, 0.03 | 0.10 | -0.15 | -0.31, 0.01 | 0.07 | -0.13 | -0.29, 0.03 | 0.10 |