PREDO, BMI-defined metabolome, SD units | ITU, BMI-related PMRS VIPa 0.7 SD units | ITU, BMI-related PMRS VIP 1.0 SD units | ITU, BMI-related PMRS VIP 1.2 SD units | ITU, BMI-related PMRS VIP 1.4 SD units | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR/MD | 95% CI | p | OR/MD | 95% CI | p | OR/MD | 95% CI | p | OR/MD | 95% CI | p | OR/MD | 95% CI | p | |
Maternal pregnancy compications | |||||||||||||||
GDM, yes vs. no | 2.52 | 1.92, 3.31 | < 0.0001 | 1.61 | 1.28, 2.03 | < 0.0001 | 1.63 | 1.29, 2.06 | < 0.0001 | 1.66 | 1.31, 2.09 | < 0.0001 | 1.66 | 1.31, 2.09 | < 0.0001 |
Hypertensive pregnancy disorders | |||||||||||||||
Normotension | Ref | Ref | Ref | Ref | Ref | ||||||||||
Gestational hypertension, yes vs. no | 1.46 | 1.00, 2.12 | 0.05 | 1.89 | 0.91, 3.92 | 0.09 | 1.83 | 0.88, 3.81 | 0.11 | 1.88 | 0.90, 3.91 | 0.09 | 2.01 | 0.97, 4.14 | 0.06 |
Preeclampsia, yes vs. no | 2.24 | 1.56, 3.24 | < 0.0001 | 2.04 | 1.18, 3.52 | 0.01 | 2.08 | 1.20, 3.61 | 0.009 | 1.94 | 1.13, 3.34 | 0.02 | 1.92 | 1.12, 3.29 | 0.02 |
Chronic hypertension, yes vs. no | 2.26 | 1.66, 3.07 | < 0.0001 | 1.49 | 0.60, 3.73 | 0.39 | 1.47 | 0.59, 3.68 | 0.41 | 1.46 | 0.59, 3.63 | 0.42 | 1.65 | 0.66, 4.09 | 0.28 |
Gestational weight gain | |||||||||||||||
Normal | Ref | Ref | Ref | Ref | Ref | ||||||||||
Inadequate, yes vs. no | 1.72 | 1.15, 2.58 | 0.008 | 0.90 | 0.70, 1.16 | 0.41 | 0.92 | 0.72, 1.18 | 0.53 | 0.93 | 0.72, 1.19 | 0.54 | 0.93 | 0.73, 1.19 | 0.57 |
Exessive, yes vs. no | 1.63 | 1.14, 2.35 | 0.008 | 1.05 | 0.84, 1.30 | 0.68 | 1.05 | 0.85, 1.31 | 0.63 | 1.02 | 0.82, 1.27 | 0.83 | 1.04 | 0.84, 1.29 | 0.74 |
Birth outcomes | |||||||||||||||
Caesarian section vs. vaginal delivery | 1.28 | 1.00, 1.64 | 0.05 | 1.28 | 1.02, 1.61 | 0.03 | 1.29 | 1.02, 1.62 | 0.03 | 1.31 | 1.04, 1.65 | 0.02 | 1.33 | 1.06, 1.67 | 0.02 |
Gestational age, weeks | -0.30 | -0.50, -0.09 | 0.005 | -0.15 | -0.30, 0.00 | 0.06 | -0.15 | -0.30, 0.00 | 0.05 | -0.14 | -0.29, 0.01 | 0.06 | -0.14 | -0.29, 0.01 | 0.07 |
Preterm birth, yes vs. no | 1.54 | 1.06, 2.23 | 0.02 | 1.15 | 0.74, 1.78 | 0.54 | 1.13 | 0.73, 1.75 | 0.60 | 1.08 | 0.70, 1.68 | 0.73 | 1.15 | 0.74, 1.78 | 0.53 |
NICU treatment, yes vs. no | 1.63 | 1.25, 2.14 | 0.0003 | 1.42 | 1.05, 1.92 | 0.02 | 1.39 | 1.03, 1.88 | 0.03 | 1.37 | 1.01, 1.85 | 0.04 | 1.41 | 1.05, 1.91 | 0.02 |
Birth weight, grams | 91.84 | 46.59, 137.08 | < 0.0001 | 34.48 | -2.40, 71.35 | 0.07 | 33.47 | -3.43, 70.37 | 0.08 | 27.67 | -9.41, 64.75 | 0.14 | 19.08 | -18.00, 56.13 | 0.31 |
Child neurodevelopment | |||||||||||||||
Number of areas of child neurodevelopmental delayb | 1.48 | 1.18, 1.87 | 0.0008 | 1.00 | 0.79, 1.25 | 0.97 | 0.99 | 0.70, 1.25 | 0.95 | 1.00 | 0.79, 1.25 | 0.97 | 0.98 | 0.78, 1.24 | 0.88 |
Bayley Scales of Infant and Toddler Development, raw units | |||||||||||||||
Receptive language development | -0.03 | -0.30, 0.24 | 0.81 | -0.04 | -0.30, 0.23 | 0.78 | -0.06 | -0.32, 0.21 | 0.67 | -0.05 | -0.31, 0.22 | 0.73 | |||
Expressive language development | 0.05 | -0.31, 0.41 | 0.77 | 0.02 | -0.34, 0.38 | 0.93 | 0.06 | -0.30, 0.42 | 0.75 | 0.07 | -0.29, 0.43 | 0.72 | |||
Fine motor development | 0.20 | -0.14, 0.54 | 0.25 | 0.19 | -0.14, 0.53 | 0.26 | 0.18 | -0.15, 0.52 | 0.29 | 0.21 | -0.13, 0.55 | 0.23 | |||
Gross motor development | -0.09 | -0.38, 0.20 | 0.54 | -0.11 | -0.40, 0.17 | 0.43 | -0.14 | -0.43, 0.16 | 0.36 | -0.13 | -0.43, 0.17 | 0.38 | |||
Cognitive development | -0.30 | -0.58, -0.01 | 0.04 | -0.30 | -0.58, -0.01 | 0.04 | -0.30 | -0.59, -0.01 | 0.04 | -0.24 | -0.53, 0.05 | 0.10 |