Outcomes | Number of included studies per type of comparator group | Sample size (exposed cases/total exposed) (unexposed cases/total unexposed) | OR and 95% CI | I²; tau² |
---|---|---|---|---|
Neuro-developmental disorders as a whole | n = 4 unexposed, WWE; n = 1 unexposed (not otherwise specified) | 84/5271 456/22,230 | 0.84 [0.66;1.06] | 0%; 0 |
Language disorders or delay | n = 2 unexposed, WWE; n = 4 unexposed, disease free; n = 1 unexposed (not otherwise specified) | 15a/313 50a/506 | 1.16 [0.67;2.00] | 58%; 0.29 |
Psychomotor developmental disorders or delay | n = 2 unexposed, disease free; n = 1 unexposed, WWE; n = 1 unexposed (not otherwise specified) | 1a/163 2a/220 | 2.68 [1.29;5.56] | 9%; 0.07 |
Diagnosis or risk of ADHD | n = 3 unexposed, WWE; n = 1 unexposed (not otherwise specified) | 3a/ 113a 4a/11,530 | 1.14 [0.75;1.72] | 0%; 0 |
Diagnosis or risk of ASD | n = 4 unexposed, WWE; n = 1 unexposed, disease free | 63a/5262a 358a/33,313 | 0.97 [0.61;1.53] | 30%; 0.08 |
n = 2 unexposed, WWE; n = 1 unexposed, disease free | 50/5186 268/21,743 | 0.81 [0.59;1.11] | 0%; 0 | |
Cognitive developmental delay (< 3 years old) | n = 1 unexposed, WWE; n = 1 unexposed, disease free | 5a/42 2a/86 | 3.42 [1.17;9.98] | 0%; 0 |
Cognitive developmental delay (3–6 years old) | n = 2 unexposed, disease free; n = 1 unexposed (not otherwise specified) | 1a/79 2a/146 | 3.39 [0.56;20.57] | 68%; 1.70 |
Cognitive developmental delay (> 6 years old) | n = 2 unexposed, WWE; n = 1 unexposed, disease free | 12a/113 30a/124 | 0.75 [0.41;1.37] | 0%; 0 |
Severe cognitive developmental delay (Mental retardation) – children (3–6 years old) | n = 1 unexposed, disease free | 0/35 1/44 | 0.41 [0.02;10.40] | - |
Severe cognitive developmental delay (Mental retardation) – children (> 6 years old) | n = 1 unexposed, WWE | 21/5073 139/21,634 | 0.73 [0.46; 1.16] | - |
Learning disorders | n = 1 unexposed, WWE; n = 1 unexposed, disease free | 5a/125 4a/224 | 1.45 [0.82;2.54] | 0%; 0 |