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Table 2 Stimulation characteristics and outcomes of PCOS and tubal transferred cohorts on D3, D4, and D5

From: Which transfer day results in the highest live birth rate for PCOS patients undergoing in vitro fertilization?

 

PCOS

P-value

Tubal factor Infertility

P-value

n = 242

n = 1422

D3

D4

D5

D3

D4

D5

Cycles

81

117

44

 

486

768

168

 

Gn(day)

11.84 ± 2.80

11.88 ± 2.91

11.41 ± 2.71

0.628

11.60 ± 1.61

11.59 ± 1.82

11.63 ± 1.46

0.954

Gn amount (IU)

2076.85 ± 767.48*

2530.41 ± 1016.26**

2114.77 ± 932.45

0.001

2511.86 ± 697.67

2537.42 ± 740.79

2451.04 ± 654.43

0.356

Number of oocytes

14.68 ± 5.06

13.87 ± 4.80**

16.98 ± 5.92***

0.003

11.44 ± 5.25*

12.64 ± 4.73**

14.63 ± 5.37***

0.000

Fertilization method

   

0.500

   

0.775

IVF

66.67(54/81)

65.81(77/117)

56.82(25/44)

 

81.48(396/486)

82.03(630/768)

83.93(141/168)

 

ICSI

33.33(27/81)

34.19(40/117)

43.18(19/44)

 

18.52(90/486)

17.97(138/768)

16.07(27/168)

 

Available embryo rate, %

43.86(325/741)

42.61(496/1164)

43.62(236/541)

0.846

45.00(1599/3553)

46.59(3222/6915)

46.02(873/1897)

0.303

E2 of HCG (pg/mL)

3276.37 ± 1569.93

3141.89 ± 1363.39**

3884.80 ± 1351.19***

0.014

2958.84 ± 1603.28*

3142.54 ± 1436.51**

3726.75 ± 1599.49***

0.000

P of HCG (ng/mL)

0.64 ± 0.31

0.59 ± 0.22

0.63 ± 0.25

0.351

0.81 ± 0.31

0.79 ± 0.27

0.83 ± 0.30

0.216

Endometrium thickness(mm)

10.49 ± 2.19*

11.82 ± 2.10**

11.37 ± 2.07***

0.000

11.29 ± 2.22

11.43 ± 2.14

11.7 ± 2.21

0.106

No. Of embryos per ET cycle

2.00 ± 0.00*

1.71 ± 0.46**

1.55 ± 0.50***

0.000

1.98 ± 0.16*

1.72 ± 0.45**

1.57 ± 0.50***

0.000

Pregnancy rate, %

51.85(42/81)*

76.92(90/117)**

61.36(27/44)

0.001

60.91(296/486)

63.02(484/768)

61.31(103/168)

0.735

Implantation rate, %

35.19(57/162)*

60(120/200)

55.88(38/68)***

0.000

41.88(402/960)*

49.01(646/1318)

53.41(141/264)***

0.000

Ectopic pregnancy rate, %

4.76(2/42)

1.11(1/90)

3.70(1/27)

0.418

1.69(5/296)

0.41(2/484)

1.94(2/103)

0.139

Miscarriage rate, %

35.71(15/42)*

13.33(12/90)

25.93(7/27)

0.011

15.54(46/296)

14.46(70/484)

16.50(17/103)

0.837

Multiple pregnancy rate, %

35.71(15/42)

33.33(30/90)

40.74(11/27)

0.777

35.47(105/296)

33.26(161/484)

36.89(38/103)

0.701

Live birth rate, %

32.10(26/81)*

65.81(77/117)**

43.18(19/44)

0.000

50.41(245/486)

53.65(412/768)

50.00(84/168)

0.452

  1. * D3 VS D4 P <0.05; ** D4 VS D5 P <0.05; ***D3 VS D5 P <0.05;
  2. A patient with D3 PCOS pregnancy had a live birth after intrauterine and extrauterine surgery
  3. Gn: gonadotropin; IVF: in vitro fertilization; ICSI: intracytoplasmic sperm injection; P: progesterone