Table 3 Genome-wide significant associations with glucose metabolism in gravid populations
Gene | SNP | Chromosome | Effect allele in GDM | Effect allele frequency | FPG | 1hPG | 2hPG | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta | SE | P value | Beta | SE | P value | Beta | SE | P value | |||||
TRPV3 | rs62069863 | 17 | A | 0.349 | 1.07E-03 | 2.95E-03 | 7.18E-01 | 0.490 | 0.133 | 2.60E-04 | 0.491 | 0.123 | 8.12E-05 |
PRMT6 | rs2232016 | 1 | T | 0.158 | 3.01E-03 | 3.79E-03 | 4.27E-01 | 0.762 | 0.169 | 9.12E-06 | 0.575 | 0.159 | 3.28E-04 |
HHEX/EXOC6 | rs1112718 | 10 | A | 0.142 | 1.19E-02 | 4.12E-03 | 4.04E-03 | 0.744 | 0.187 | 8.10E-05 | 0.695 | 0.173 | 7.34E-05 |
GLIS3 | rs927316 | 9 | G | 0.205 | -4.04E-03 | 3.56E-03 | 2.57E-01 | -0.256 | 0.163 | 1.16E-01 | -0.424 | 0.150 | 4.96E-03 |
LPIN2 | rs10460009 | 18 | C | 0.496 | 1.41E-02 | 5.35E-03 | 8.97E-03 | 0.639 | 0.245 | 9.48E-03 | 0.821 | 0.226 | 3.13E-04 |