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Table 3 Multinomial logistic regression analysis of the associations between mid-pregnancy glucose status and specific congenital heart defect subtypes

From: Associations of elevated glucose levels at each time point during OGTT with fetal congenital heart diseases: a cohort study of 72,236 births

Variable

AVSD

Othera

n (%)

OR (95%CI)

P value

n (%)

OR (95%CI)

P value

GDM

 No

265 (0.5)

1 (Ref)

 

112 (0.2)

1 (Ref)

 

 Yes

118 (0.8)

1.48 (1.18 ~ 1.84)

0.001

38 (0.2)

1.25 (0.86 ~ 1.82)

0.242

OGTT 0 h

  < 5.1 mmol/L

331 (0.5)

1 (Ref)

 

129 (0.2)

1 (Ref)

 

  ≥ 5.1 mmol/L

52 (0.7)

1.32 (0.98 ~ 1.77)

0.069

21 (0.3)

1.47 (0.93 ~ 2.35)

0.102

OGTT 1 h

  < 10 mmol/L

318 (0.5)

1 (Ref)

 

138 (0.2)

1 (Ref)

 

  ≥ 10 mmol/L

65 (0.9)

1.6 (1.22 ~ 2.11)

0.001

12 (0.2)

0.77 (0.42 ~ 1.4)

0.388

OGTT 2 h

  < 8.5 mmol/L

331 (0.5)

1 (Ref)

 

129 (0.2)

1 (Ref)

 

  ≥ 8.5 mmol/L

52 (0.8)

1.33 (0.99 ~ 1.8)

0.061

21 (0.3)

1.63 (1.02 ~ 2.62)

0.041

OGTT statusb

 Group 1

265 (0.5)

1 (Ref)

 

112 (0.2)

1 (Ref)

 

 Group 2

30 (0.6)

1.21 (0.83 ~ 1.77)

0.333

14 (0.3)

1.39 (0.8 ~ 2.43)

0.247

 Group 3

66 (0.8)

1.53 (1.16 ~ 2.01)

0.003

17 (0.2)

1.05 (0.63 ~ 1.76)

0.858

 Group 4

22 (1.1)

1.91 (1.23 ~ 2.99)

0.004

7 (0.4)

1.72 (0.79 ~ 3.74)

0.169

P for trend

  

 < 0.001

  

0.257

  1. All models adjusted for infant sex, maternal age, assisted reproduction, gestational hypertension, gravidity, parity, and gestational week of delivery
  2. Abbreviations: AVSD atrial or ventricular septal defect, GDM gestational diabetes mellitus, OGTT oral glucose tolerance test
  3. a Congenital heart defect other than atrial or ventricular septal defect, and patent ductus arteriosus
  4. b OGTT status: Group 1 represents OGTT 0 h, 1 h and 2 h are both normal; Group 2 indicates that OGTT 0 h is abnormal, while OGTT 1 h and 2 h is normal; Group 3 indicates that OGTT 0 h is normal, while OGTT 1 h or 2 h is abnormal; Group 4 represents OGTT 0 h,1 h and 2 h are all abnormal. Adjusted for infant sex, maternal age, assisted reproduction, gestational hypertension, gravidity, parity, and gestational week of delivery