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Table 5 Association between the IL-19 (rs1028181 (T/C) and rs2243191 (T/C)) polymorphisms and preeclampsia risk markers in preeclampsia and control groups

From: Highlighting allelic variations at the interleukin-19 locus in term of preeclampsia predisposing factors and access to an accurate diagnostic/screening option

rs1028181 (T/C)

Genotypes n (%)

P-value

rs2243191(T/C)

Genotypes n (%)

P-value

CC

TT

CT

CC

TT

CT

Seizures Present

1 (100)

0 (0)

0 (0)

0.005

Seizures Present

0 (0)

1 (100)

0 (0)

0.003

Absent

66 (43.7)

18 (10.3)

65 (46)

Absent

93 (60.8)

49 (33.8)

8 (5.4)

Proteinuria Absent

9 (17)

20 (37.7)

24 (45.3)

0.023

Proteinuria Absent

4 (7.5)

18 (34)

31 (58.5)

0.056

Trace

2 (11.1)

7 (38.9)

9 (50)

Trace

1 (5.6)

6 (33.3)

11 (61.1)

1

7 (15.2)

6 (40)

24 (52.2)

1

1 (2.2)

17 (37)

28 (60.9)

2

1 (6.7)

10 (71.4)

8 (53.3)

2

3 (20)

4 (26.7)

8 (53.3)

3

2 (14.3)

1 (25)

2 (14.3)

3

2 (14.3)

5 (35.7)

7 (50)

4

2 (50)

15 (32.6)

1 (25)

4

1 (25)

2 (50)

1 (25)

Edema Absent

3 (13)

11 (47.8)

9 (39.1)

0.093

Edema Absent

2 (8.7)

4 (17.4)

17 (73.9)

0.017

1

15 (16.5)

34 (37.4)

42 (46.2)

1

10 (11)

35 (38.5)

46 (50.5)

2

3 (12)

11 (44)

11 (44)

2

0 (0)

10 (40)

15 (60)

3

2 (18.2)

3 (27.3)

6 (54.5)

3

0 (0)

3 (27.3)

8 (72.7)

Diabetes Present

2 (22.2)

2 (22.2)

5 (55.6)

0.054

Diabetes Present

0 (0)

5 (55.6)

4 (44.4)

0.023

Absent

31 (14.9)

57 (40.4)

63 (44.7)

Absent

12 (8.5)

47 (33.3)

82 (58.2)

Hyperthyroidism Present

5 (29.4)

4 (23.5)

8 (47.1)

0.015

Hyperthyroidism Present

0 (0)

5 (29.4)

12 (70.6)

0.032

Absent

18 (13.5)

55 (41.4)

60 (45.1)

Absent

12 (9)

47 (35.3)

74 (55.6)

HELLP syndrome Present

6 (20)

11 (36.7)

13 (43.3)

0.072

HELLP syndrome Present

13 (43.3)

14 (46.7)

9 (7.5)

0.041

Absent

17 (14.2)

48 (40)

55 (45.8)

Absent

9 (7.5)

39 (32.5)

72 (60)

Maternal smoking Yes

3 (17.64)

11 (64.70)

3 (17.64)

0.022

Maternal smoking Yes

11 (64.70)

5 (29.41)

1 (5.88)

0.094

No

58 (43.60)

48 (36.09)

27 (20.31)

No

91 (68.42)

36 (27.06)

6 (4.51)

Maternal BMI <18.5

13 (61)

3 (17)

5 (22)

0.045

Maternal BMI <18.5

0 (0)

19 (100)

0 (0)

0.012

18.5–24.9

68 (78)

9 (10)

14 (12)

18.5–24.9

11 (7.9)

70 (81)

13 (11.1)

25–29.9

20 (72)

3 (24)

7 (4)

25–29.9

0 (0)

21 (93)

4 (7)

≥30

4 (82)

2 (9)

2 (9)

≥30

3 (13.4)

7 (82.4)

2 (4.2)

rs1028181 (T/C)

Genotypes n (%)

P-value

rs2243191(T/C)

Genotypes n (%)

P-value

CC

TT

CT

CC

TT

CT

Seizures Present

Seizures Present

0.003

1 (100)

0 (0)

0 (0)

0.005

0 (0)

1 (100)

0 (0)

Absent

66 (43.7)

18 (10.3)

65 (46)

Absent

93 (60.8)

49 (33.8)

8 (5.4)

Proteinuria Absent

9 (17)

20 (37.7)

24 (45.3)

0.023

Proteinuria Absent

4 (7.5)

18 (34)

31 (58.5)

0.056

Trace

2 (11.1)

7 (38.9)

9 (50)

Trace

1 (5.6)

6 (33.3)

11 (61.1)

1

7 (15.2)

6 (40)

24 (52.2)

1

1 (2.2)

17 (37)

28 (60.9)

2

1 (6.7)

10 (71.4)

8 (53.3)

2

3 (20)

4 (26.7)

8 (53.3)

3

2 (14.3)

1 (25)

2 (14.3)

3

2 (14.3)

5 (35.7)

7 (50)

4

2 (50)

15 (32.6)

1 (25)

4

1 (25)

2 (50)

1 (25)

Edema Absent

3 (13)

11 (47.8)

9 (39.1)

0.093

Edema Absent

2 (8.7)

4 (17.4)

17 (73.9)

0.017

1

15 (16.5)

34 (37.4)

42 (46.2)

1

10 (11)

35 (38.5)

46 (50.5)

2

3 (12)

11 (44)

11 (44)

2

0 (0)

10 (40)

15 (60)

3

2 (18.2)

3 (27.3)

6 (54.5)

3

0 (0)

3 (27.3)

8 (72.7)

Diabetes Present

2 (22.2)

2 (22.2)

5 (55.6)

0.054

Diabetes Present

0 (0)

5 (55.6)

4 (44.4)

0.023

Absent

31 (14.9)

57 (40.4)

63 (44.7)

Absent

12 (8.5)

47 (33.3)

82 (58.2)

Hyperthyroidism Present

5 (29.4)

4 (23.5)

8 (47.1)

0.015

Hyperthyroidism Present

0 (0)

5 (29.4)

12 (70.6)

0.032

Absent

18 (13.5)

55 (41.4)

60 (45.1)

Absent

12 (9)

47 (35.3)

74 (55.6)

HELLP syndrome Present

6 (20)

11 (36.7)

13 (43.3)

0.072

HELLP syndrome Present

13 (43.3)

14 (46.7)

9 (7.5)

0.041

Absent

17 (14.2)

48 (40)

55 (45.8)

Absent

9 (7.5)

39 (32.5)

72 (60)

Maternal smoking Yes

3 (17.64)

11 (64.70)

3 (17.64)

0.022

Maternal smoking Yes

11 (64.70)

5 (29.41)

1 (5.88)

0.094

No

58 (43.60)

48 (36.09)

27 (20.31)

No

91 (68.42)

36 (27.06)

6 (4.51)

Maternal BMI <18.5

13 (61)

3 (17)

5 (22)

0.045

Maternal BMI <18.5

0 (0)

19 (100)

0 (0)

0.012

18.5–24.9

68 (78)

9 (10)

14 (12)

18.5–24.9

11 (7.9)

70 (81)

13 (11.1)

25–29.9

20 (72)

3 (24)

7 (4)

25–29.9

0 (0)

21 (93)

4 (7)

≥30

4 (82)

2 (9)

2 (9)

≥30

3 (13.4)

7 (82.4)

2 (4.2)

  1. Data presented as n (%). Significance level of values is 0.05. P-values were calculated with chi-square-test
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