Reduction in spontaneous and iatrogenic preterm births in twin pregnancies during COVID-19 lockdown in Melbourne, Australia: a multicenter cohort study

Table 3 Infant outcomes in the pre-pandemic, exposure 1 and exposure 2 cohorts

Outcomes	Pre-pandemic		Exposure 1		Exposure 2		Exposure 1 aRR			Exposure 2 aRR
Outcomes	n = 2438	58%	n = 866	19%	n = 1230	27%	aRR	95% CI	P value	aRR	95% CI	P value
All-cause stillbirths^a	38	3.1	13	3.0	26	4.2	1.00	0.99–1.01	0.80	1.00	0.99–1.01	0.622
All-cause stillbirths	38	1.6	13	1.5	26	2.1	1.00	0.99–1.01	0.82	1.00	0.99–1.01	0.63
Fetal Growth Restriction	145	6.0	49	5.7	70	5.7	1.00	0.98–1.02	0.74	1.00	0.98–1.02	0.88
SCN admissions	1058	43.4	333	38.5	431	35.0	0.91	0.87–0.95	< 0.001	0.87	0.84–0.91	< 0.001
NICU admissions	478	19.6	171	19.8	307	25.0	0.99	0.95–1.02	0.45	1.06	1.03–1.10	< 0.001
5-min APGAR < 7 (all gestations)	174	7.2	60	7.0	121	10.02	0.98	0.97–1.00	0.06	0.97	1.00–1.05	0.02
Congenital anomalies^a	106	4.4	40	4.6	49 4.0		0.98	0.97–1.00	0.06	0.97	0.96–0.99	< 0.001

aRR Adjusted risk ratio, CI Confidence interval, SCN Special care nursery, NICU Neonatal intensive care unit
^aDenominator is all pregnancies

ISSN: 1471-2393