Table 3 Summary results of the association between rheumatoid arthritis and fetal outcomes

Premature delivery [3, 4, 6, 9, 10, 20, 21, 26, 28,29,30, 32, 35, 36, 42,43,44,45,46, 48,49,50]

22

1.57 (1.00, 2.48)

0.052

98.8

Stillbirth [9, 27, 35, 38, 40, 44]

6

1.55 (1.17, 2.06)

0.003

0.0

SGA [3, 6, 21, 30, 32, 35, 36, 42, 45, 46, 48,49,50]

13

1.48 (1.25, 1.75)

< 0.001

85.4

Region

 Europe

1.55 (1.15, 2.09)

0.004

53.9

 North America

1.46 (1.12, 1.89)

0.005

89.5

 Asia

1.42 (1.01, 2.00)

0.047

89.7

 Birth weight [4, 9, 20, 24, 28, 29, 50]

7

-135.10 (-244.27, -25.94)

0.015

97.7

Study design

 Cohort study

-173.78 (-295.12, -52.43)

0.005

98.2

 Case-control study

-23.25 (-330.96, 284.47)

0.882

92.6

Region

 Europe

-71.64 (-146.99, 3.72)

0.062

82.9

 North America

-162.00 (-235.49, -88.51)

< 0.001

78.6

 Asia

-342.59 (-362.97, -322.22)

< 0.001

NA

 LBW [3, 4, 18, 27, 29, 30, 32, 36, 43, 45, 46, 48]

12

1.73 (1.46, 2.06)

< 0.001

65.8

Study design

 Cohort study

1.75 (1.46, 2.09)

< 0.001

72.2

 Case-control study

1.16 (0.29, 4.57)

0.833

66.4

 Cross-sectional study

1.99 (0.72, 5.51)

0.183

NA

Region

 Europe

1.41 (0.87, 2.28)

0.161

33.0

 North America

1.80 (1.45, 2.25)

< 0.001

52.8

 Asia

1.72 (1.19, 2.49)

0.004

84.8

 Africa

1.99 (0.72, 5.51)

0.183

NA

Apgar score at 5 min below 7 [35, 38, 46]

3

1.05 (0.71, 1.54)

0.818

63.2

Requiring intensive care [9, 18, 21, 26]

4

1.93 (0.82, 4.56)

0.133

56.0

Infantile autism [25, 33, 39]

3

1.41 (0.76, 2.61)

0.278

0.0

Congenital abnormalities [3, 4, 9, 18, 21, 26, 29, 35, 45,46,47,48,49,50]

12

1.24 (1.13, 1.37)

< 0.001

42.3

Diabetes type 1 [5, 6]

2

1.70 (1.41, 2.06)

< 0.001

36.8

Asthma [5, 41]

2

1.23 (1.16, 1.30)

< 0.001

0.0