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Table 2 Comparison of baseline characteristics between AI and HT

From: Clinical insights of pregnancy management, adrenal insufficiency as a possible cause of elevated TSH: a pilot study of case series

 

Group 1

Group 2

Group 3

P-value

Total

Early

Mid

Total

Early

Total

Early

Mid

Late

1 vs 2*

1 vs 3*

Cases, n

4

3

1

3

3

6

1

3

2

  

Variables

           

Pregnacy, weeks

14.3 ± 2.5

13.3 ± 2.1

17

 

11.3 ± 4

23.7 ± 7.9

14

21.3 ± 5.5

32 ± 1.4

n. s.

n. s.

Age, yr

35.0 ± 4.8

36.3 ± 4.9

31

 

30.0 ± 7.5

32.2 ± 5.9

41

29.7 ± 5.1

31.5 ± 4.9

n. s.

n. s.

BMI, kg/m2

27.2 ± 6.9

28.2 ± 8.1

24.2

 

19.2 ± 2.1

23.5 ± 4.0

22.8

21.5 ± 2.9

26.8 ± 5.4

n. s.

n. s.

WBC, ×102/µL

81.8 ± 16.5

80.3 ± 19.9

86

 

74.3 ± 19.1

80.2 ± 16.4

80

77 ± 12.2

85 ± 31.1

n. s.

n. s.

Eosino, %

2.9 ± 1.1

2.4 ± 0.6

4.4

 

1.3 ± 0.9

1.0 ± 0.5

0.8

1.1 ± 0.8

1

0.0215

0.0043

Hb, g/dL

11.4 ± 0.5

11.7 ± 0.3

10.8

 

11.5 ± 0.8

11.6 ± 0.9

11.9

11.6 ± 1.4

11.6 ± 0.2

n. s.

n. s.

Na, mEq/L

136.7 ± 1.0

136.6 ± 1.2

137

 

138 ± 1.0

138.3 ± 1.5

137

138 ± 1.7

139.5 ± 0.7

n. s.

n. s.

K, mEq/L

4.1 ± 0.2

4.1 ± 0.2

4

 

4.2 ± 0.3

3.8 ± 0.3

3.8

3.5 ± 0.5

3.9 ± 0.1

n. s.

n. s.

LDL-C, mg/dL

106.8 ± 14.0

100 ± 7.9

127

 

75 ± 29.8

128.8 ± 22.2

117

119.3 ± 9.7

149 ± 32.5

n. s.

n. s.

TG, mg/dL

159.8 ± 62.1

130 ± 19.1

81

 

108 ± 12.5

199.5 ± 70.9

336

184.7 ± 28.1

153.5 ± 4.9

n. s.

n. s.

HbA1c, %

5.2 ± 0.26

5.2 ± 0.3

4.9

 

5.2 ± 0.3

5.4 ± 0.3

5.7

5.2

5.5 ± 0.4

n. s.

n. s.

TSH, µIU/mL

2.4 ± 1.8

2.98 ± 1.7

0.81

 

5.9 ± 4.8

3.2 ± 1.9

1.2

4.7 ± 1.5

2.0 ± 0.4

n. s.

n. s.

FT4, ng/dL

1.1 ± 0.2

1.1 ± 0.3

1.1

 

1.1 ± 0.1

1.0 ± 0.2

0.99

1.0 ± 0.3

1.0 ± 0.1

n. s.

n. s.

TgAb, U/mL

7.6

(2.2, 36.7)

10

(1.2, 45.6)

5.1

 

92.97

(2.9, 183)

1.1

(0.7, 4.0)

0.78

1.3

(0.8, 10)

1.2

(0.5, 2.0)

n. s.

n. s.

TPOAb, U/mL

3.14

(0.7, 12.3)

5

(1.3, 14.7)

0.5

 

12.4

(0.5,1450)

0.8

(0.5, 3.4)

0.5

1.2

(1.2, 10)

0.5

n. s.

n. s.

ACTH, µg/dL

17.9 ± 10.0

19.0 ± 12

14.8

 

13.4 ± 4.8

14.6 ± 5.9

9

18.8 ± 5.3

26.8 ± 5.4

n. s.

n. s.

TUS

           

diffuse thyroid

parenchyma,

n (%)

2(50)

1(33.3)

1(100)

 

1(33.3)

1(16.7)

0(0)

1(33.3)

0(0)

n. s.

n. s.

Estimated weight, g

13.3 ± 14.5

20.1 ± 19.1

13.1

 

11.3 ± 7.9

8.0 ± 0.9

8.8

8.2 ± 1.2

7.4 ± 0.4

n. s.

n. s.

  1. AI, adrenal insufficiency; HT, hypothyroidism
  2. Group 1; AI group, Group 2; hypothyroid group with low basal serum cortisol but pass stimulation test, Group 3; hypothyroid group with adequate basal serum cortisol. Early, early pregnancy (1~15w); Mid, mid-pregnancy (16 ~ 27w); Late, late pregnancy (28w~)
  3. BMI, body mass index; ALB, albumin; LDL-C, LDL cholesterol; TG, Triglyceride; HbA1c, hemoglobin A1c; TgAb, thyroglobulin autoantibodies; TPOAb, thyroid peroxidase antibodies; BC, Basal Cortisol; TUS, Thyroid Ultrasound; n. s., not significant
  4. Continuous and categorical data are expressed as the mean ± standard deviation or median (interquartile range) and number (%), respectively
  5. *Comparison of values between patients (Group 1 vs. Group 2 and Group 1 vs. Group 3) using Pearson’s chi-square test for categorical variables and using Student’s t-test and the Wilcoxon signed-rank test for normally distributed and skewed continuous variables, respectively
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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