Table 10 Neonatal outcomes, by subgroups
Outcome | Subgroup (recruited women relevant to each subgroup with baby data available in intervention; control groups) | Intervention | Control | Risk ratio [95% CI] or Mean Difference [95% CI] |
|---|---|---|---|---|
Live-born before 37 weeks (% of live-born)a | Trial as a whole (1163; 777) | 62 (5.3) | 50 (6.4) | 0.81 [0.56, 1.17] |
Germany (457; 280) | 18 (3.9) | 16 (5.7) | 0.61 [0.31, 1.21] | |
Ireland (358; 249) | 19 (5.3) | 10 (4.0) | 1.23 [0.59, 2.56] | |
Italy (348; 248) | 25 (7.2) | 24 (9.7) | 0.77 [0.45, 1.32] | |
Vaginal birth before previous CS (104; 54) | 8 (7.7) | 7 (13.0) | 0.67 [0.26, 1.71] | |
No vaginal births before previous CS (1059; 723) | 54 (5.1) | 43 (5.9) | 0.83 [0.56, 1.24] | |
Prior VBAC (74; 32) | 3 (4.1) | 1 (3.1) | 0.87 [0.13, 6.02] | |
No prior VBAC (1089; 745) | 59 (5.4) | 49 (6.6) | 0.81 [0.56, 1.17] | |
Recruitment at < 30 weeks (619; 461) | 44 (7.1) | 31 (6.7) | 0.98 [0.62, 1.56] | |
Recruitment at 30–32 weeks (104; 44) | 7 (6.7) | 5 (11.4) | 0.73 [0.26, 2.11] | |
Recruitment at ≥33 weeks (438; 270) | 11 (2.5) | 13 (4.8) | 0.51 [0.24, 1.10] | |
BMI (< 25.00) (553; 309) | 25 (4.5) | 21 (6.8) | 0.64 [0.37, 1.11] | |
BMI (25–29.99) (347; 268) | 23 (6.6) | 15 (5.6) | 1.19 [0.61, 2.33] | |
BMI (> 29.99) (202; 175) | 10 (5.0) | 14 (8.0) | 0.77 [0.34, 1.77] | |
Age (< 40 years) (1072; 702) | 55 (5.1) | 40 (5.7) | 0.88 [0.59, 1.32] | |
Age (≥40 years) (91; 72) | 7 (7.7) | 9 (12.5) | 0.63 [0.26, 1.52] | |
Gestational age at birth (mean, SD)b | Trial as a whole (1163; 777) | 38.9 (1.5) | 38.7 (1.8) | 0.15 [0.00, 0.30] |
Germany (457; 280) | 38.9 (1.4) | 39.0 (1.8) | −0.10 [−0.35, 0.15] | |
Ireland (358; 249) | 39.1 (1.5) | 39.0 (1.7) | 0.10 [−0.16, 0.36] | |
Italy (348; 248) | 38.6 (1.7) | 38.1 (1.6) | 0.50 [0.23, 0.77] | |
Vaginal birth before previous CS (104; 54) | 38.7 (1.9) | 38.4 (2.0) | 0.30 [−0.35, 0.95] | |
No vaginal births before previous CS (1059; 723) | 38.9 (1.5) | 38.7 (1.7) | 0.20 [0.05, 0.35] | |
Prior VBAC (74; 32) | 39.0 (1.5) | 39.4 (1.4) | −0.40 [−0.99, 0.19] | |
No prior VBAC (1089; 745) | 38.9 (1.6) | 38.7 (1.8) | 0.20 [0.04, 0.36] | |
Recruitment at < 30 weeks (619; 461) | 38.7 (1.7) | 38.7 (1.8) | 0.00 [−0.21, 0.21] | |
Recruitment at 30–32 weeks (104; 44) | 38.7 (1.5) | 38.3 (1.9) | 0.40 [−0.23, 1.03] | |
Recruitment at ≥33 weeks (438; 270) | 39.1 (1.3) | 38.9 (1.5) | 0.20 [−0.02, 0.42] | |
BMI (< 25.00) (553; 309) | 38.9 (1.5) | 38.8 (1.7) | 0.10 [−0.13, 0.33] | |
BMI (25–29.99) (347; 268) | 38.9 (1.6) | 38.7 (1.7) | 0.20 [−0.06, 0.46] | |
BMI (> 29.99) (202; 175) | 38.8 (1.5) | 38.5 (1.9) | 0.30 [−0.05, 0.65] | |
Age (< 40 years) (1072; 702) | 38.9 (1.6) | 38.8 (1.7) | 0.10 [−0.06, 0.26] | |
Age (≥40 years) (91; 72) | 38.6 (1.5) | 38.3 (1.8) | 0.30 [−0.22, 0.82] | |
Admission to NICU (% of live-born)c | Trial as a whole (1163; 777) | 90 (7.7) | 63 (8.1) | 0.87 [0.64, 1.17] |
Germany (457; 280) | 34 (7.4) | 28 (10.0) | 0.58 [0.35, 0.95] | |
Ireland (358; 249) | 40 (11.2) | 28 (11.2) | 0.97 [0.62, 1.51] | |
Italy (348; 248) | 16 (4.6) | 7 (2.8) | 1.70 [0.73, 3.93] | |
Vaginal birth before previous CS (104; 54) | 11 (10.6) | 6 (11.1) | 0.97 [0.43, 2.21] | |
No vaginal births before previous CS (1059; 723) | 79 (7.5) | 57 (7.9) | 0.85 [0.62, 1.18] | |
Prior VBAC (74; 32) | 8 (10.8) | 4 (12.5) | 0.93 [0.34, 2.58] | |
No prior VBAC (1089; 745) | 82 (7.5) | 59 (7.9) | 0.87 [0.64, 1.20] | |
Recruitment at < 30 weeks (619; 462) | 60 (9.7) | 40 (8.7) | 1.08 [0.74, 1.58] | |
Recruitment at 30–32 weeks (104; 44) | 6 (5.8) | 4 (9.1) | 0.68 [0.22, 2.11] | |
Recruitment at ≥33 weeks (438; 270) | 23 (5.3) | 19 (7.0) | 0.63 [0.36, 1.11] | |
BMI (< 25.00) (553; 309) | 40 (7.2) | 25 (8.1) | 0.91 [0.56, 1.48] | |
BMI (25–29.99) (347; 268) | 29 (8.4) | 16 (6.0) | 0.96 [0.54, 1.70] | |
BMI (> 29.99) (202; 175) | 17 (8.4) | 21 (12.0) | 0.56 [0.31, 1.01] | |
Age (< 40 years) (1072; 702) | 86 (8.0) | 60 (8.5) | 0.87 [0.64, 1.19] | |
Age (≥40 years) (91; 72) | 4 (4.4) | 3 (4.2) | 0.72 [0.17, 2.99] |