Table 4 Pregnancy outcomes with respect to initiation time of treatment among treatment group

Initiated treatment in the first trimester

(≤12 weeks)^a

3 (0.4)

40 (5.9)

20 (2.9)

1 (0.1)

8 (1.2)

5 (0.7)

0 (0)

Initiated treatment in the second trimester (13 weeks - 27 weeks)

6 (0.6)

48 (5.2)

37 (4.0)

6 (0.6)

13 (1.4)

4 (0.4)

11 (1.2)

OR (95% CI)^b

1.41 (0.35–5.69)

0.89 (0.58–1.37)

1.35 (0.78–2.36)

4.24 (0.51–35.39)

1.20 (0.49–2.92)

0.57 (0.15–2.13)

/

P

0.634

0.588

0.287

0.183

0.685

0.399

/

Initiated treatment in the third trimester

(≥28 weeks)

23 (1.9)

150 (12.2)

104 (8.4)

5 (0.4)

26 (2.1)

5 (0.4)

34 (2.8)

OR (95% CI)^b

4.48 (1.31–15.30)

2.34 (1.61–3.40)

3.25 (1.97–5.37)

2.48 (0.28–21.86)

1.84 (0.81–4.17)

0.46 (0.13–1.69)

2.26 (1.11–4.61)^c

P

0.017

< 0.001

< 0.001

0.413

0.142

0.243

0.025

P for trend

0.003

< 0.001

< 0.001

0.622

0.109

0.252

< 0.001