Diagnostic accuracy of maternal serum multiple marker screening for early detection of gestational diabetes mellitus in the absence of a gold standard test

Table 2 The estimated diagnostic accuracy parameters for composite test from Bayesian latent class model adjusting for maternal age and BMI

Biomarker	Parameter	Mean	Median	SD	MC error	95% CrI
uE3 and β-hCG
	cSensitivity	0.68	0.66	0.14	0.01	0.64–0.75
	cSpecificity	0.66	0.65	0.22	0.02	0.61–0.77
	cAUC	0.70	0.70	0.11	0.01	0.62–0.78
uE3 and AFP
	cSensitivity	0.76	0.78	0.36	0.01	0.70–0.82
	cSpecificity	0.72	0.71	0.15	0.01	0.66–0.78
	cAUC	0.87	0.87	0.14	0.02	0.81–0.91
AFP and β-hCG
	cSensitivity	0.72	0.74	0.42	0.05	0.68–0.81
	cSpecificity	0.75	0.75	0.23	0.01	0.68–0.84
	cAUC	0.79	0.78	0.21	0.02	0.71–0.87
uE3 and β-hCG and AFP
	cSensitivity	0.94	0.95	0.06	0.001	0.91–0.99
	cSpecificity	0.86	0.86	0.15	0.02	0.80–0.92
	cAUC	0.92	0.91	0.11	0.01	0.87–0.98

uE3 unconjugated estriol, β-hCG beta-human chorionic gonadotropin, AFP alfa-fetoprotein, SD standard deviation, MC monte carlo, CrI credible interval, cSensitivity combined Sensitivity, cSpecificity combined Specificity, cAUC combined area under receiver operating characteristic curve

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