Approach | Threshold | ≥Threshold n (%) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | Positive LR (95% CI) | Negative LR (95% CI) | NNT | NNS |
---|---|---|---|---|---|---|---|---|---|---|
Women without high-risk factors, n = 12,125 | ||||||||||
NICE approach | Screen-positivea | 903 (7.4) | 28% (23–34%) | 93% (93–94%) | 8% (7–10%) | 98% (98–99%) | 4.07 (3.32–4.99) | 0.77 (0.71–0.83) | 122 | 1639 |
WS base model | 3.9%b | 912 (7.5) | 29% (24–35%) | 93% (92–93%) | 8% (7–10%) | 98% (98–99%) | 4.15 (3.40–5.07) | 0.76 (0.70–0.82) | 120 | 1595 |
All women, n = 12,395 | ||||||||||
NICE approach | Screen-positivea | 1173 (9.5) | 37% (31–42%) | 91% (91–92%) | 9% (8–11%) | 98% (98–99%) | 4.15 (3.53–4.87) | 0.70 (0.64–0.76) | 110 | 1158 |
WS final model | 3.8%b | 1205 (9.7) | 38% (33–44%) | 91% (90–91%) | 9% (8–11%) | 98% (98–99%) | 4.23 (3.62–4.95) | 0.68 (0.62–0.74) | 108 | 1107 |