Determinants of influenza vaccination uptake in pregnancy: a large single-Centre cohort study

Table 1 Factors associated with uptake of influenza vaccination during pregnancy according to mothers’ characteristics (n = 2045)

	Vaccinated
	n/N^a	%	p^¥
Total	725/2045	35.5
Age
< 25 years	97/306	31.7	0.49
≥ 25 and < 30 years	230/645	35.7
≥ 30 and < 35 years	246/685	35.9
≥ 35 years	151/408	37.0
Educational level
Primary	28/69	40.6	0.59
Secondary or technical	132/386	34.2
Higher study	564/1588	35.5
Lives with partner
Yes	643/1803	35.7	0.56
No	81/240	33.7	0.56
Smoked during pregnancy
Yes	144/437	33.0	0.22
No	578/1602	36.1	0.22
At least one comorbidity^b	191/478	40.0	0.02
Respiratory	48/142	33.8
Cardiac	28/74	37.8
Neurological	36/93	38.7
Nephrological	9/18	50.0
Haematologic-immune	31/54	57.4
Diabetes	16/30	53.3
Chronic liver disease	10/21	47.6
BMI ≥ 40 kg/m²	13/24	29.5
Previous influenza vaccination
Yes, outside pregnancy	279/548	50.9	< 0.001
Yes, during a previous pregnancy	185/201	92.0
No	249/1235	20.2
Number of previous deliveries
0	358/874	41.0	< 0.001
1	225/704	32.0
≥ 2	141/465	30.3
History of preterm delivery < 34 weeks
Yes	33/76	43.4	0.14
No	691/1967	35.1	0.14
Obstetric complications^c
Yes	288/812	35.5	0.98
No	435/1228	35.4	0.98
Perceived frequency of influenza in the general population
Very low to low	49/180	27.2	0.02
Intermediate	217/631	34.4
High	452/1202	37.6
Perceived frequency of vaccine complications in pregnant women
Very low	352/673	52.3	< 0.001
Low	154/509	30.3
Intermediate	139/597	23.3
High	52/141	36.9
Perceived frequency of vaccine complications in babies
Very low	375/687	54.6	< 0.001
Low	122/414	29.5
Intermediate	128/621	20.6
High	64/181	35.4
Good knowledge of influenza^±
Yes	374/606	61.7	< 0.001
No	351/1439	24.4	< 0.001

^aNumber of women vaccinated among the total number of women in the subclass
^bPresence of at least one comorbidity that is an indication for influenza vaccination even outside of pregnancy according to the 2012 HAS guidelines [32]
^cGestational diabetes, hypertension, pre-eclampsia, HELLP syndrome, infections, other (anaemia, foetal growth restriction, etc.)
¥p value was calculated by Chi 2 test
±good knowledge of influenza was defined by a knowledge score > 5.4/9

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