Fig. 5

Effects of α7nAChR activation on monocyte cytokine release. Peripheral blood monocytes isolated from nonpregnant (NP), normotensive pregnant (NT), and preeclamptic (PE) women were treated with or without an α7nAChR agonist PNU-282987 for 24 h, then TNF-α (a), IL-1β (b), IL-6 (c), and IL-10 (d) levels in the supernatant were measured. **p < 0.01 vs. the vehicle group of the NP and NT groups; ^#p < 0.05, ^##p < 0.01 vs. the PE group treated with vehicle (two-way ANOVA followed by Bonferroni post-test, groups of NP, NT and PE were entered as the between-subjects factor, treatments of vehicle and PNU-282987 were entered as the within-subjects factor)