Table 4 Risk of HDP in antidepressant and/or anxiolytic users before the 16th week of gestation

No

(n = 6502)

1

1

PE (n = 111); GH (n = 186)

Before the 16th week of pregnancy

(n = 218)

PE risk

3.16 (1.68–5.98)†

PE risk (n = 11)

3.09 (1.56–6.12)‡

GH risk

1.53 (0.77–3.02)

GH risk (n = 9)

1.39 (0.66–2.92)

ᅟContinued their medication after the 16th week

ᅟ(n = 167)

PE risk

3.80 (1.95–7.40)†

PE risk (n = 10)

3.41 (1.66–7.02)†

GH risk

1.57 (0.72–3.39)

GH risk (n = 7)

1.28 (0.56–2.96)

ᅟStopped their medication before the 16th week

ᅟ(n = 51)

PE risk

1.19 (0.16–8.67)

PE risk (n = 1)

1.60 (0.21–12.34)

GH risk

1.40 (0.34–5.80)

GH risk (n = 2)

1.93 (0.42–8.92)

Non medicated depression/anxiety during pregnancy

(n = 41)

PE risk

3.00 (0.71–12.58)

PE risk (n = 2)

2.92 (0.67–12.73)

GH risk

0.88 (0.12–6.47)

GH risk (n = 1)

0.77 (0.10–5.78)