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Table 2 Bivariate and Multivariate Cox-proportional hazard regression for predictors of neonatal mortality among neonates admitted to NICU of WSUTRH, South Ethiopia, 2015–2017

From: Predictors of Neonatal mortality in Neonatal intensive care unit at referral Hospital in Southern Ethiopia: a retrospective cohort study

Variables

Outcomes

p-value

Crude HR 95%CI

Adjusted HR 95%CI

event

censored

Sex of neonate

 male

112

462

1

1

1

 Female

47

343

0.003

0.59 [0.42–0.84]

0.91 [0.64–1.30]

Birth weight

 < 2500 g

104

229

<

3.41 [2.46–4.73]

1.32 [0.78–2.25]

 > = 2500 g

55

576

< 0.001

1

1

1

GA

 term

75

677

1

1

1

 Preterm

84

128

< 0.001

3.60 [2.63–4.93]

0.92 [0.48–1.78]

Birth level

 multiple

69

74

<

4.43 [3.24–6.07]

1.80 [1.10–2.94]*

 Single

90

731

0.001

1

1

1

ANC follow-up

 > 4

19

433

1

1

1

 1–3

60

286

< 0.001

4.06 [2.42–6.81]

2.76 [1.62–4.71]

 None

80

86

< 0.001

12.96 [7.86–21.39]

6.02 [3.52–10.27]**

Parity

 primipareous

86

269

< 0.001

2.11 [1.58–2.96]

1.19 [0.86–1.66]

 Multipareous

73

536

1

1

1

Mode of delivery

 SVD

136

466

1

1

1

 SVD

10

151

< 0.001

0.28 [0.15–0.53]

0.39 [0.20–0.75]

 C/S

13

188

< 0.001

0.26 [0.15–0.46]

0.34 [0.19–0.61]**

Suspected sepsis

 Yes

106

448

1

1

1

 No

53

357

0.021

0.68 [0.49–0.94]

0.83 [0.54–1.28]

Respiratory distress

 Yes

74

348

> 0.99

0.0.98 [0.73–1.36]

 No

85

457

1

1

 

PNA

 Yes

58

195

0.001

1.73 [1.25–2.39]

1.81 [1.24–2.63]*

 No

101

610

1

1

1

Congenital Malformation

 Yes

2

36

0.105

0.32 [0.08–1.28]

 

 No

157

769

1

1

HMD

 Yes

31

16

< 0.001

4.60 [3.10–6.82]

2.04 [1.16–3.59]*

 No

128

789

1

1

 

MAS

 Yes

20

129

0.217

0.74 [0.47–1.19]

 

 No

139

676

1

1

Temperature of neonate at admission

 35.5–37.5

42

537

1

1

1

 < 35.5

110

213

< 0.001

4.75 [3.33–6.78]

1.58 [1.06–2.34]*

 > 37.5

7

55

0.343

1.47 [0.66–3.28]

1.58 [0.70–3.59]

Neonate resuscitated

 Yes

122

327

< 0.001

4.49 [3.10–6.49]

2.28 [1.54–3.38]**

 No

37

478

1

1

1

Breast feeding initiated

 within 1 h

22

497

1

1

1

 after 1 h

137

308

< 0.001

7.42 [4.73–11.64]

2.62 [1.60–4.30]**

Treated by oxygen

 Yes

139

477

1

1

1

 No

20

328

< 0.001

0.27 [0.17–0.43]

0.65 [0.39–1.06]

Treated by KMC

 Yes

53

108

< 0.001

2.22 [1.59–3.09]

0.81 [0.52–1.28]

 No

106

697

1

1

Treated by antibiotics

 Yes

145

720

1

1

 No

14

14

0.93

0.97 [0.63–1.69]

 

Treated by glucose

 Yes

54

268

0.97

1.01 [0.72–1.40]

 

 No

105

697

1

1

  1. **p < 0.001, *p < 0.05, CHR-crude hazard ratio, AHR-adjusted hazard ratio and CI-confidence interval. n was the same for the crude and adjusted models