Table 3 Extent to which test characteristics affect decision vs preferred screening and diagnostic technology (numbers are averages of scores on 1–5 Likert scales, with 1 – disagreement, 5 – agreement)

NIPT is much more accurate than current screening in assessing the risk of DS

4.64

3.11

64.5%

< 0.001

Results of NIPT can be available earlier in the pregnancy than the result of current screening

4.57

2.94

62.9%

< 0.001

Current screening estimates the risk that the baby has neural tube defects and NIPT doesn’t

2.55

4.11

15.9%

< 0.001

Current screening can indicate the possibility of pregnancy and labor complications and NIPT cannot

2.40

3.98

13.4%

< 0.001

Women choosing amniocentesis

With NIPT there is no increased risk of miscarriage

4.78

2.93

66.5%

< 0.001

NIPT is more convenient than amniocentesis (only requires a blood draw)

4.24

2.61

46.9%

< 0.001

NIPT tests for the common chromosome disorders (like Down Syndrome), which is all I need to know

3.89

2.43

28.5%

< 0.001

Amniocentesis is more accurate than NIPT

2.46

4.61

24.2%

< 0.001

Amniocentesis gives more information about possible chromosome anomalies than NIPT

2.53

4.57

21.9%

< 0.001