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Table 4 Virological characteristics in HBeAg-negative carrier women in 487 pregnant women and women with different pregnant histories

From: Comparison of hepatitis B viral loads and viral antigen levels in child-bearing age women with and without pregnancy

  Nullipara
(n = 104)
Pregnancy (n = 142) 7–12 months postpartum (n = 110) 2–5 years postpartum (n = 131) p
Age (year) 25.0(22.0–30.0) 25.0 (22.8–30.3) 27.0 (23.7–31.2)a 29.5 (24.3–32.3)a, b < 0.05
HBV DNA, log IU/ml (min-max) 2.3 (1.4–6.6) 2.6 (1.6–6.7) 2.5 (1.5–7.0) 2.8 (1.4–6.0) 0.085
HBsAg, log IU/ml (min-max) 3.1 (0.9–4.8) 3.3 (0.9–4.2) 3.3 (1.0–4.3) 3.0 (1.3–4.2) 0.06
Genotypec  
B (%) 41 (51.3) 46 (33.6)d 52 (49.5)e 81 (64.8) < 0.001
C (%) 39 (48.7) 91 (66.4)d 53 (50.5)e 44 (35.2)
  1. HBeAg hepatitis B e antigen, HBsAg hepatitis B surface antigen, HBV hepatitis B virus
  2. ap < 0.05 compared with the age of nulliparas and pregnant women
  3. bp < 0.05 compared with the age of puerperant women, 7–12 months postpartum
  4. cThe HBV genotype was not determined in 37 women because HBV DNA level was too low to be detected, including 23 nulliparas, 4 pregnant women, 5 puerperants 7–12 months postpartum and 5 puerperants 2–5 years postpartum. Additionally, there were one woman infected with genotype D and another woman infected with genotype G. Since the numbers for genotypes D and G were too low to be meaningfully compared, we did not include these three women in the table
  5. dp = 0.010, 0.012, and < 0.001 compared with the frequencies of genotypes B and C in nullipara group, puerperant 7–12 months postpartum and puerperant 2–5 years postpartum respectively
  6. ep = 0.019 compared with the frequencies of genotypes B and C in puerperant 2–5 years postpartum. The differences between any other groups had no statistical significance (all p > 0.05)