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Table 1 Case subject characteristics

From: Delayed Lactogenesis II and potential utility of antenatal milk expression in women developing late-onset preeclampsia: a case series

CASES

 

1: “M”

2: “C”

3: “K”

4: “S”

STUDY DATA

 Study group assignment

AME

Education

AME

AME

  Number of intervention study visits prior to delivery (max of 4)

3

0

1

0

DEMOGRAPHICS

 Age

26

34

36

35

  Race & ethnicity

Non-Hispanic, White

Non-Hispanic, White

Hispanic, Other

Non-Hispanic, White

 Marital status

Married

Married

Married

Married

  Highest level of education

Bachelors

Some college

Bachelors

PhD

OBSTETRIC & HEALTH HISTORY

 Pre-pregnancy BMI

22.6

20.2

24.7

30.0

  Gestational weight gain (lbs)

33

57

33

32

 Relevant health history

Supraventricular tachycardia

Anxiety, depression (no medications)

N/A

Anxiety, depression (75 mg sertraline daily)

  Gravida status

1 (previous spontaneous abortion in first trimester)

0

0

0

PREECLAMPSIA/HYPERTENSIVE DISORDER

 Classification

Preeclampsia with severe features (thrombocytopenia)

Preeclampsia without severe features

Preeclampsia without severe features

Gestational hypertension (with severe range blood pressures)

  Weeks at

  diagnosis

393/7

366/7

390/7

374/7

 Magnesium sulfate administration

56.4 g over 49 h

n/a

n/a

83.8 g over 44 h

  Placenta pathology reporta

No diagnostic abnormalities; 557 g, 75th percentile

390 g, 10th percentile; Features of maternal vascular malperfusion

No diagnostic abnormalities; 383 g, 10th percentile

No diagnostic abnormalities; 353 g, 10th percentile

LABOR & DELIVERY

 Weeks gestation at delivery

394/7

370/7

391/7

375/7

  Onset of labor

Natural

Induced

Induced

Induced

 Augmentation of labor

Pitocin, misoprostol, foley bulb, artificial rupture of membranes

Misoprostol

Dinoprostone, Pitocin

Pitocin, misoprostol, foley bulb, artificial rupture of membranes

  Labor anesthesia

Epidural

Spinal, general

Epidural, spinal

Epidural

 Type of delivery (and indication)

Cesarean section (arrested dilation and worsening preeclampsia)

Cesarean section (fetal intolerance)

Cesarean section (fetal intolerance)

Vaginal

  Duration of labor in hospital (hours)

36

15

25

24

 Duration of second stage of labor (hours)

N/A

N/A

N/A

0.5

  Total intravenous fluids during labor and postpartum (mL)

8148 over 85 h

6620 over 81 h

3408 over 7 h

6816 over 41 h

POSTPARTUM

 Maternal disposition after birth

ICU

Mother-baby unit

Mother-baby unit

Mother-baby unit

  Infant disposition after birth

NICU

Well-baby nursery

Well-baby nursery

Well-baby nursery

 Infant birthweight (g)

3766

2927

2947

2580

  Infant weight change from birthweight at hospital discharge

−7.6%

− 6.6%

− 6.1%

− 6.2%

 Infant Apgar scores 1 & 5 mins

2, 7

8, 9

7, 9

6, 8

  Maternal hospital LOS (days)

4

5

4

2

 Infant hospital LOS (days)

3

4

3

2

BREASTFEEDING

 Lactation consult(s) in hospital

No

Yes (×4)

Yes (×1)

Yes (×2)

  Total volume of formula in hospital (mL)

0

455

0

199

 First at-breast feed in hospital after delivery (hours)

1.5

3.5

1.3

1.5

  First use of formula in hospital after delivery (hours)

N/A

1.5

N/A

15.5

 Milk expression in hospital (e.g., hand expression or pump)

Yes

Yes

Yes

Yes

  Maternal perception of onset of lactogenesis II

Day 5

Day 5

Day 2

Day 4

 Breastfeeding status at 1–2 weeksb

Exclusive breastfeeding

Exclusive breastfeeding

Exclusive breastfeeding

Medium partial breastfeeding

  Breastfeeding status at 3–4 monthsb

Exclusive breastfeeding

High partial breastfeeding

Exclusive breastfeeding

Exclusive breastfeeding

  1. aPercentiles are placental weights-for-gestation
  2. LOS = length of stay
  3. bBreastfeeding status classifications based upon definitions provided by Labbok and Krasovec, where exclusive breastfeeding equates with 100% of all feeds as breast milk, high partial breastfeeding is 80% or more of all feeds as breast milk, and medium partial breastfeeding is 20–80% of all feeds as breast milk
  4. Labbok M, Krasovec K. Toward consistency in breastfeeding definitions. Studies in Family Planning. 1990;21(4):226–230