Table 2 The likelihood of having good knowledge about the concept of pharmacogenetics given respondent characteristics
Characteristics | Gave positive answers to knowledge questions, adjusted OR (95% CI)a, p value | |||
|---|---|---|---|---|
Do you think that there could be differences between people in their body's response to medication due to differences in their DNA? | Do you think that determining the differences in DNA that are associated with the effect of medication will help to reduce (future) side-effects? | Do you think that knowing the differences in DNA that are associated with the effect of medication will help to improve (future) drug treatments? | Answering ‘Yes’ to all three questions (sum score of 3) | |
Educational level | ||||
Low | Reference level | |||
Middle | 4.84 (1.56-15.0), 0.006 | 1.08 (0.37-3.18), 0.88 | 1.34 (0.43-4.16), 0.62 | 1.62 (0.59-4.45), 0.35 |
High | 8.1 (2.39-27.51), 0.001 | 1.65 (0.55-4.96), 0.37 | 2.69 (0.81-8.91), 0.11 | 2.57 (0.92-7.18), 0.07 |
Living situation (Living with spouse/partner/others vs. alone/divorced) | 0.74 (0.09-6.07), 0.78 | 0.56 (0.12-2.76), 0.56 | 1.02 (0.21-5.02), 0.98 | 0.75 (0.19-3.0), 0.75 |
Having chronic disease(s)b (Yes vs. No) | 0.91 (0.36-2.32), 0.85 | 1.11 (0.55-2.23), 0.77 | 1.04 (0.47-2.32), 0.92 | 1.41 (0.72-2.875), 0.32 |
Having chronic disease(s)c (Yes vs. No) | 0.88 (0.38-2.0), 0.75 | 1.47 (0.80-2.71), 0.21 | 1.27 (0.63-2.56), 0.50 | 1.70 (0.96-3.02), 0.071 |
Used medication during pregnancy (Yes vs. No/Do not know) | 0.99 (0.44-2.26), 0.99 | 1.62 (0.88-2.96), 0.12 | 1.40 (0.70-2.79), 0.34 | 1.23 (0.70-2.18), 0.47 |
Experienced side effectb (Yes vs. No/Do not know) | 1.97 (0.82-4.74), 0.13 | 1.45 (0.79-2.67), 0.23 | 2.13 (1.02-4.45), 0.045 | 1.65 (0.93-2.94), 0.09 |
Experienced side effectc (Yes vs. No/Do not know) | 2.66 (1.11-6.40), 0.029 | 1.74 (0.95-3.20), 0.073 | 2.56 (1.24-5.29), 0.011 | 2.06 (1.16-3.65), 0.014 |
Stopping medication due to side effect(s) (Yes vs. No/do not know) | 0.98 (0.42-2.32), 0.97 | 1.30 (0.68-2.48), 0.43 | 1.08 (0.52-2.24), 0.84 | 1.47 (0.80-2.71), 0.22 |
Stopping medication due to inefficacy (Yes vs. No/Do not know) | 1.10 (0.42-2.90), 0.85 | 1.06 (0.52-2.14), 0.88 | 0.60 (0.28-1.27), 0.18 | 0.97 (0.50-1.88), 0.93 |
Aware of the term ‘pharmacogenetics’ | 4.08 (0.93-17.91), 0.063 | 1.37 (0.64-2.93), 0.42 | 1.79 (0.70-4.58), 0.22 | 1.57 (0.77-3.19), 0.22 |
Aware of the meaning of ‘pharmacogenetics’ | 2.88 (0.65-12.75), 0.16 | 1.53 (0.65-3.60), 0.33 | 3.01 (0.87-10.36), 0.081 | 1.80 (0.80-4.07), 0.16 |