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Table 4 The ePTB subgroup predicted /observed probability and maternal characteristics in validation cohort via logistic regression

From: Subgroup identification of early preterm birth (ePTB): informing a future prospective enrichment clinical trial design

Variable

Subgroup

1st Quartile

2nd Quartile

3rd Quartile

4th Quartile

N = 299529

N = 299078

N = 299993

N = 299861

Probability (%)

 Average Predicted

1.92

2.46

3.22

6.02

 Range Predicted

0.55

0.52

0.95

60.6

 Average Observed

1.83

2.33

3.24

6.07

Mothers’ Age (%)

  ≤ 24 Years

36603 (12.22)

70681 (23.63)

127739 (42.58)

105995 (35.35)

 25-29 Years

120779 (40.32)

83600 (27.95)

68003 (22.67)

71979 (24.00)

 30-34 Years

129538 (43.25)

78439 (26.23)

56362 (18.79)

60927 (20.32)

  ≥ 35 Years

12609 (4.21)

66358 (22.19)

47889 (15.96)

60960 (20.33)

Mothers’ Race (%)

 White

259978 (86.80)

273311 (91.38)

260128 (86.71)

114119 (38.06)

 Black

0 (0.00)

872 (0.29)

18661 (6.22)

172970 (57.68)

 American Indian/Alaskan Native/Asian or Pacific Islander

39551 (13.20)

24895 (8.32)

21204 (7.07)

12772 (4.26)

Marital Status (%)

 Married

296804 (99.09)

246717 (82.49)

92320 (30.77)

80790 (26.94)

 Unmarried

2725 (0.91)

52361 (17.51)

207673 (69.23)

219071 (73.06)

Mothers’ Education (%)

  ≤ High School or GED/Unknown

10988 (3.67)

93778 (31.36)

192086 (64.03)

175699 (58.59)

 Associate/Some College Credit

69843 (23.32)

117843 (39.40)

69455 (23.15)

79732 (26.59)

  ≥ Bachelor’s

217614 (72.65)

71541 (23.92)

21886 (7.30)

35359 (11.79)

 Missing

1084 (0.36)

15916 (5.32)

16566 (5.52)

9071 (3.03)

Pre-pregnancy Smoking Status (%)

 Nonsmoker

295313 (98.59)

262159 (87.66)

234907 (78.30)

217556 (72.55)

 Smoker/Unknown/Not Stated

3132 (1.05)

21003 (7.02)

48520 (16.17)

73234 (24.42)

 Missing

1084 (0.36)

15916 (5.32)

16566 (5.52)

9071 (3.03)

Pre-pregnancy BMI (%)

 Under Weight-Normal ≤ 24.9

183032 (61.11)

142007 (47.48)

119757 (39.92)

108130 (36.06)

 Overweight 25.0-29.9

82956 (27.70)

67818 (22.68)

70451 (23.48)

62770 (20.93)

 Obesity ≥ 30.0/Unknown/Not Stated

32457 (10.84)

73337 (24.52)

93219 (31.07)

119890 (39.98)

 Missing

1084 (0.36)

15916 (5.32)

16566 (5.52)

9071 (3.03)

Pre-pregnancy Diabetes Status (%)

 No/Unknown/Not Stated

298445 (99.64)

283149 (94.67)

282480 (94.16)

282746 (94.29)

 Yes

0 (0.00)

13 (0.00)

947 (0.32)

8044 (2.68)

 Missing

1084 (0.36)

15916 (5.32)

16566 (5.52)

9071 (3.03)

Pre-pregnancy Hypertension Status (%)

 No/Unknown/Not Stated

298445 (99.64)

283162 (94.68)

282293 (94.10)

273911 (91.35)

 Yes

0 (0.00)

0 (0.00)

1134 (0.38)

16879 (5.63)

 Missing

1084 (0.36)

15916 (5.32)

16566 (5.52)

9071 (3.03)

Previous Preterm Birth Status (%)

 No/Unknown/Not Stated

298445 (99.64)

283162 (94.68)

283427 (94.48)

258817 (86.31)

 Yes

0 (0.00)

0 (0.00)

0 (0.00)

31973 (10.66)

 Missing

1084 (0.36)

15916 (5.32)

16566 (5.52)

9071 (3.03)

Infertility Treatment Usage Status (%)

 No/Unknown/Not Stated

298445 (99.64)

283162 (94.68)

283427 (94.48)

272918 (91.01)

 Yes

0 (0.00)

0 (0.00)

0 (0.00)

17872 (5.96)

 Missing

1084 (0.36)

15916 (5.32)

16566 (5.52)

9071 (3.03)