Figure 4

Daily comparison during long-term treatment. Representative IUP values from treatment day 7 in pregnant monkeys continuously IV infused with saline (control in green), 150 μg kg^-1 h^-1 barusiban (in orange), or 3μg kg^-1 h^-1 fenoterol (in yellow) [17]. All groups were challenged daily with OT infusion for 3–6 hours (represented by the pink bar). Barusiban was effective in suppressing OT-induced increases in uterine contractility, whereas fenoterol was not. Barusiban was statistically superior to the OT control on 8/17 days and better than fenoterol on 11/17 days. Data shown are means ± SEM. Intervals without SEM are data for individual animals, which occurred because of varying duration of OT infusion or limited post-OT measurements. The unit of the integrated half-hour IUP intervals [kmmHg h] is kilo millimetre mercury times hour.