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Table 3 Outcomes of children at 5 years by gestational age at birth and ACS groupings

From: Association between gestational age at birth, antenatal corticosteroids, and outcomes at 5 years: multiple courses of antenatal corticosteroids for preterm birth study at 5 years of age (MACS-5)

 

Preterm (<30 weeks) N = 200

Preterm (30–36 weeks) N = 1066

Term (≥37 weeks) N = 462

Outcome

Multiple ACS N = 105

Single ACS N = 95

Multiple ACS N = 553

Single ACS N = 504

Multiple ACS N = 213a

Single ACS N = 249

Death or severe disability (neuromotor, neurosensory, neurocognitive)§

54/105 (51.4%)

50/95 (52.6%)

115/553 (20.8%)

122/504 (24.2%)

48/213 (22.5%)

38/249 (15.3%)

Death up to 5 years

29/105 (27.6%)

23/95 (24.2%)

16/555 (2.9%)

22/511 (4.3%)

1/213 (0.5%)

2/249 (0.8%)

Neuromotor disability †† (non-ambulatory cerebral palsy)

1/76 (1.3%)

6/72 (8.3%)

3/539 (0.6%)

4/489 (0.8%)

0/212 (0%)

1/247 (0.4%)

Neurosensory disability

13/76 (17.1%)

13/72 (18.1%)

38/539 (7.1%)

41/489 (8.4%)

19/212 (9.0%)

7/247 (2.8%)

Needing visual aids

9/76 (11.8%)

11/72 (15.3%)

35/539 (6.5%)

34/489 (7.0%)

17/212 (8.0%)

7/247 (2.8%)

Deafness

4/76 (5.3%)

2/72 (2.8%)

4/539 (0.7%)

3/489 (0.6%)

3/212 (1.4%)

1/247 (0.4%)

Pre-existing (diagnosed at 2 years or earlier)

3

2

1

2

0

0

New (diagnosed after 2 years of age)

1

0

3

1

3

1

Neurocognitive/neurobehavioural disability

15/76 (19.7%)

16/69 (23.2%)

62/534 (11.6%)

63/478 (13.2%)

31/212 (14.6%)

30/246 (12.2%)

  1. ACS= antenatal corticosteroid.
  2. a1 child lost to follow-up earlier in trial found and included at 5 years.
  3. §Clinical information of 19 cases missing/inadequate questionnaires were reviewed by an adjudication committee (10 cases were adjudicated to contribute to analysis and primary outcome; 9 had insufficient information).
  4. ††non-ambulatory cerebral palsy was defined as Gross Motor Function Classification System III, IV or V.