Variables | Total (n = 2,824,418) | SC (n = 2,789,398) | ART (n = 35,020) | P |
---|---|---|---|---|
Maternal age at delivery, years, Mean ± SD | 29.61 ± 5.54 | 29.53 ± 5.50 | 35.84 ± 4.87 | < 0.001 |
Age subgroups, n (%) |  |  |  | < 0.001 |
<35 years | 2,263,460 (80.14) | 2,249,290 (80.64) | 14,170 (40.46) | Â |
≥35years | 560,958 (19.86) | 540,108 (19.36) | 20,850 (59.54) |  |
Race of mother, n (%) |  |  |  | < 0.001 |
White | 2,156,689 (76.36) | 2,129,552 (76.34) | 27,137 (77.49) | Â |
Black | 357,342 (12.65) | 355,554 (12.75) | 1,788 (5.11) | Â |
Others | 105,102 (3.72) | 104,379 (3.74) | 723 (2.06) | Â |
Asian | 205,285 (7.27) | 199,913 (7.17) | 5,372 (15.34) | Â |
Educational level of mother, n (%) |  |  |  | < 0.001 |
Less than high school | 81,575 (2.89) | 81,475 (2.92) | 100 (0.29) | Â |
High school | 859,126 (30.42) | 857,181 (30.73) | 1,945 (5.55) | Â |
Bachelor or above | 1,849,939 (65.50) | 1,818,076 (65.18) | 31,863 (90.99) | Â |
Unknown | 33,778 (1.20) | 32,666 (1.17) | 1,112 (3.18) | Â |
Marital status, n (%) |  |  |  | < 0.001 |
Unmarried | 789,496 (27.95) | 788,170 (28.26) | 1,326 (3.79) | Â |
Married | 1,677,120 (59.38) | 1,648,773 (59.11) | 28,347 (80.95) | Â |
Unknown | 357,802 (12.67) | 352,455 (12.64) | 5,347 (15.27) | Â |
Age of father, years, Mean ± SD | 31.95 ± 6.67 | 31.87 ± 6.64 | 38.13 ± 6.39 | < 0.001 |
Race of father, n (%) |  |  |  | < 0.001 |
White | 1,942,863 (68.79) | 1,916,519 (68.71) | 26,344 (75.23) | Â |
Black | 388,297 (13.75) | 386,438 (13.85) | 1,859 (5.31) | Â |
Other | 95,417 (3.38) | 94,760 (3.40) | 657 (1.88) | Â |
Asian | 174,795 (6.19) | 170,426 (6.11) | 4,369 (12.48) | Â |
Unknown | 223,046 (7.90) | 221,255 (7.93) | 1,791 (5.11) | Â |
Educational level of father, n (%) |  |  |  | < 0.001 |
Less than high school | 99,839 (3.53) | 99,710 (3.57) | 129 (0.37) | Â |
High school | 1,050,212 (37.18) | 1,046,720 (37.52) | 3,492 (9.97) | Â |
Bachelor or above | 1,602,222 (56.73) | 1,572,117 (56.36) | 30,105 (85.97) | Â |
Unknown | 72,145 (2.55) | 70,851 (2.54) | 1,294 (3.70) | Â |
Smoking before pregnancy, n (%) |  |  |  | < 0.001 |
No | 2,667,141 (94.43) | 2,632,337 (94.37) | 34,804 (99.38) | Â |
Yes | 157,277 (5.57) | 157,061 (5.63) | 216 (0.62) | Â |
Smoking during pregnancy, n (%) |  |  |  | < 0.001 |
No | 2,706,508 (95.83) | 2,671,586 (95.78) | 34,922 (99.72) | Â |
Yes | 117,910 (4.17) | 117,812 (4.22) | 98 (0.28) | Â |
Total number of prenatal care visits for this pregnancy, number, M (Q1, Q3) | 11.00 (9.00, 13.00) | 11.00 (9.00, 13.00) | 12.00 (10.00, 14.00) | < 0.001 |
Pre-pregnancy BMI, kg/m2, Mean ± SD | 27.24 ± 6.57 | 27.25 ± 6.58 | 26.02 ± 5.70 | < 0.001 |
Pre-pregnancy chronic diabetes, n (%) | Â | Â | Â | 0.023 |
No | 2,799,766 (99.13) | 2,765,091 (99.13) | 34,675 (99.01) | Â |
Yes | 24,652 (0.87) | 24,307 (0.87) | 345 (0.99) | Â |
Gestational diabetes, n (%) |  |  |  | < 0.001 |
No | 2,603,840 (92.19) | 2,572,908 (92.24) | 30,932 (88.33) | Â |
Yes | 220,578 (7.81) | 216,490 (7.76) | 4,088 (11.67) | Â |
Gestational hypertension, n (%) |  |  |  | < 0.001 |
No | 2,590,390 (91.71) | 2,559,677 (91.76) | 30,713 (87.70) | Â |
Yes | 234,028 (8.29) | 229,721 (8.24) | 4,307 (12.30) | Â |
Eclampsia, n (%) | Â | Â | Â | 0.100 |
No | 2,817,716 (99.76) | 2,782,794 (99.76) | 34,922 (99.72) | Â |
Yes | 6,702 (0.24) | 6,604 (0.24) | 98 (0.28) | Â |
PIH, n (%) |  |  |  | < 0.001 |
No | 2584,830 (91.52) | 2,554,194 (91.57) | 30,636 (87.48) | Â |
Yes | 239,588 (8.48) | 235,204 (8.43) | 4,384 (12.52) | Â |
Clinical chorioamnionitis or maternal fever during labor, n (%) |  |  |  | < 0.001 |
No | 2,779,538 (98.41) | 2,745,595 (98.43) | 33,943 (96.92) | Â |
Yes | 44,880 (1.59) | 43,803 (1.57) | 1,077 (3.08) | Â |
Previous preterm births, n (%) | Â | Â | Â | 0.224 |
No | 2,733,365 (96.78) | 2,699,434 (96.77) | 33,931 (96.89) | Â |
Yes | 91,053 (3.22) | 89,964 (3.23) | 1,089 (3.11) | Â |
Previous cesarean section, n (%) | Â | Â | Â | 0.481 |
No | 2,389,278 (84.59) | 2,359,606 (84.59) | 29,672 (84.73) | Â |
Yes | 435,140 (15.41) | 429,792 (15.41) | 5,348 (15.27) | Â |
Parity, n (%) |  |  |  | < 0.001 |
Primipara | 1,095,213 (38.78) | 1,075,044 (38.54) | 20,169 (57.59) | Â |
Multipara | 1,729,205 (61.22) | 1,714,354 (61.46) | 14,851 (42.41) | Â |
Gestational weight gain, pounds, M (Q1, Q3) | 29.00 (20.00, 38.00) | 29.00 (20.00, 38.00) | 29.00 (21.00, 37.00) | 0.415 |
Gestational age, weeks, Mean ± SD | 38.75 ± 1.97 | 38.75 ± 1.96 | 38.54 ± 2.17 | < 0.001 |
Adverse neonatal outcomes, n (%) |  |  |  | < 0.001 |
No | 2,399,677 (84.96) | 2,371,792 (85.03) | 27,885 (79.63) | Â |
Yes | 424,741 (15.04) | 417,606 (14.97) | 7,135 (20.37) | Â |
Neonatal weight, g, Mean ± SD | 3,324.07 ± 521.64 | 3,324.12 ± 521.27 | 3,320.24 ± 549.90 | 0.189 |
Low birth weight, n (%) |  |  |  | < 0.001 |
No | 2,672,002 (94.60) | 2,639,294 (94.62) | 32,708 (93.40) | Â |
Yes | 152,416 (5.40) | 150,104 (5.38) | 2,312 (6.60) | Â |
Premature birth, n (%) |  |  |  | < 0.001 |
No | 2,569,761 (90.98) | 2,539,204 (91.03) | 30,557 (87.26) | Â |
Yes | 254,657 (9.02) | 250,194 (8.97) | 4,463 (12.74) | Â |
NICU admission, n (%) |  |  |  | < 0.001 |
No | 2,621,722 (92.82) | 2,590,534 (92.87) | 31,188 (89.06) | Â |
Yes | 202,696 (7.18) | 198,864 (7.13) | 3,832 (10.94) | Â |