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Table 1 Maternal and neonatal characteristics

From: Mediation effect of pregnancy-induced hypertension on the association between assisted reproductive technology and adverse neonatal outcomes: a population-based study

Variables

Total (n = 2,824,418)

SC (n = 2,789,398)

ART (n = 35,020)

P

Maternal age at delivery, years, Mean ± SD

29.61 ± 5.54

29.53 ± 5.50

35.84 ± 4.87

< 0.001

Age subgroups, n (%)

   

< 0.001

<35 years

2,263,460 (80.14)

2,249,290 (80.64)

14,170 (40.46)

 

≥35years

560,958 (19.86)

540,108 (19.36)

20,850 (59.54)

 

Race of mother, n (%)

   

< 0.001

White

2,156,689 (76.36)

2,129,552 (76.34)

27,137 (77.49)

 

Black

357,342 (12.65)

355,554 (12.75)

1,788 (5.11)

 

Others

105,102 (3.72)

104,379 (3.74)

723 (2.06)

 

Asian

205,285 (7.27)

199,913 (7.17)

5,372 (15.34)

 

Educational level of mother, n (%)

   

< 0.001

Less than high school

81,575 (2.89)

81,475 (2.92)

100 (0.29)

 

High school

859,126 (30.42)

857,181 (30.73)

1,945 (5.55)

 

Bachelor or above

1,849,939 (65.50)

1,818,076 (65.18)

31,863 (90.99)

 

Unknown

33,778 (1.20)

32,666 (1.17)

1,112 (3.18)

 

Marital status, n (%)

   

< 0.001

Unmarried

789,496 (27.95)

788,170 (28.26)

1,326 (3.79)

 

Married

1,677,120 (59.38)

1,648,773 (59.11)

28,347 (80.95)

 

Unknown

357,802 (12.67)

352,455 (12.64)

5,347 (15.27)

 

Age of father, years, Mean ± SD

31.95 ± 6.67

31.87 ± 6.64

38.13 ± 6.39

< 0.001

Race of father, n (%)

   

< 0.001

White

1,942,863 (68.79)

1,916,519 (68.71)

26,344 (75.23)

 

Black

388,297 (13.75)

386,438 (13.85)

1,859 (5.31)

 

Other

95,417 (3.38)

94,760 (3.40)

657 (1.88)

 

Asian

174,795 (6.19)

170,426 (6.11)

4,369 (12.48)

 

Unknown

223,046 (7.90)

221,255 (7.93)

1,791 (5.11)

 

Educational level of father, n (%)

   

< 0.001

Less than high school

99,839 (3.53)

99,710 (3.57)

129 (0.37)

 

High school

1,050,212 (37.18)

1,046,720 (37.52)

3,492 (9.97)

 

Bachelor or above

1,602,222 (56.73)

1,572,117 (56.36)

30,105 (85.97)

 

Unknown

72,145 (2.55)

70,851 (2.54)

1,294 (3.70)

 

Smoking before pregnancy, n (%)

   

< 0.001

No

2,667,141 (94.43)

2,632,337 (94.37)

34,804 (99.38)

 

Yes

157,277 (5.57)

157,061 (5.63)

216 (0.62)

 

Smoking during pregnancy, n (%)

   

< 0.001

No

2,706,508 (95.83)

2,671,586 (95.78)

34,922 (99.72)

 

Yes

117,910 (4.17)

117,812 (4.22)

98 (0.28)

 

Total number of prenatal care visits for this pregnancy, number, M (Q1, Q3)

11.00 (9.00, 13.00)

11.00 (9.00, 13.00)

12.00 (10.00, 14.00)

< 0.001

Pre-pregnancy BMI, kg/m2, Mean ± SD

27.24 ± 6.57

27.25 ± 6.58

26.02 ± 5.70

< 0.001

Pre-pregnancy chronic diabetes, n (%)

   

0.023

No

2,799,766 (99.13)

2,765,091 (99.13)

34,675 (99.01)

 

Yes

24,652 (0.87)

24,307 (0.87)

345 (0.99)

 

Gestational diabetes, n (%)

   

< 0.001

No

2,603,840 (92.19)

2,572,908 (92.24)

30,932 (88.33)

 

Yes

220,578 (7.81)

216,490 (7.76)

4,088 (11.67)

 

Gestational hypertension, n (%)

   

< 0.001

No

2,590,390 (91.71)

2,559,677 (91.76)

30,713 (87.70)

 

Yes

234,028 (8.29)

229,721 (8.24)

4,307 (12.30)

 

Eclampsia, n (%)

   

0.100

No

2,817,716 (99.76)

2,782,794 (99.76)

34,922 (99.72)

 

Yes

6,702 (0.24)

6,604 (0.24)

98 (0.28)

 

PIH, n (%)

   

< 0.001

No

2584,830 (91.52)

2,554,194 (91.57)

30,636 (87.48)

 

Yes

239,588 (8.48)

235,204 (8.43)

4,384 (12.52)

 

Clinical chorioamnionitis or maternal fever during labor, n (%)

   

< 0.001

No

2,779,538 (98.41)

2,745,595 (98.43)

33,943 (96.92)

 

Yes

44,880 (1.59)

43,803 (1.57)

1,077 (3.08)

 

Previous preterm births, n (%)

   

0.224

No

2,733,365 (96.78)

2,699,434 (96.77)

33,931 (96.89)

 

Yes

91,053 (3.22)

89,964 (3.23)

1,089 (3.11)

 

Previous cesarean section, n (%)

   

0.481

No

2,389,278 (84.59)

2,359,606 (84.59)

29,672 (84.73)

 

Yes

435,140 (15.41)

429,792 (15.41)

5,348 (15.27)

 

Parity, n (%)

   

< 0.001

Primipara

1,095,213 (38.78)

1,075,044 (38.54)

20,169 (57.59)

 

Multipara

1,729,205 (61.22)

1,714,354 (61.46)

14,851 (42.41)

 

Gestational weight gain, pounds, M (Q1, Q3)

29.00 (20.00, 38.00)

29.00 (20.00, 38.00)

29.00 (21.00, 37.00)

0.415

Gestational age, weeks, Mean ± SD

38.75 ± 1.97

38.75 ± 1.96

38.54 ± 2.17

< 0.001

Adverse neonatal outcomes, n (%)

   

< 0.001

No

2,399,677 (84.96)

2,371,792 (85.03)

27,885 (79.63)

 

Yes

424,741 (15.04)

417,606 (14.97)

7,135 (20.37)

 

Neonatal weight, g, Mean ± SD

3,324.07 ± 521.64

3,324.12 ± 521.27

3,320.24 ± 549.90

0.189

Low birth weight, n (%)

   

< 0.001

No

2,672,002 (94.60)

2,639,294 (94.62)

32,708 (93.40)

 

Yes

152,416 (5.40)

150,104 (5.38)

2,312 (6.60)

 

Premature birth, n (%)

   

< 0.001

No

2,569,761 (90.98)

2,539,204 (91.03)

30,557 (87.26)

 

Yes

254,657 (9.02)

250,194 (8.97)

4,463 (12.74)

 

NICU admission, n (%)

   

< 0.001

No

2,621,722 (92.82)

2,590,534 (92.87)

31,188 (89.06)

 

Yes

202,696 (7.18)

198,864 (7.13)

3,832 (10.94)

 
  1. Note: SC, spontaneous conception; ART, assisted reproductive technology; BMI, body mass index; PIH, pregnancy-induced hypertension; NICU, neonatal intensive care unit