Skip to main content

Methods of induction of labor and women’s experience: a population-based cohort study with mediation analyses

Abstract

Background

Negative childbirth experience may affect mother wellbeing and health. However, it is rarely evaluated in studies comparing methods of induction of labor (IoL).

Aim

To compare women’s experience of IoL according to the method, considering the mediating role of interventions and complications of delivery.

Methods

We used data from the MEDIP prospective population-based cohort, including all women with IoL during one month in seven French perinatal networks. The experience of IoL, assessed at 2 months postpartum, was first compared between cervical ripening and oxytocin, and secondarily between different cervical ripening methods. Mediation analyses were used to measure the direct and indirect effects of cervical ripening on maternal experience, through delivery with interventions or complications.

Findings

The response rate was 47.8% (n = 1453/3042). Compared with oxytocin (n = 541), cervical ripening (n = 910) was associated less often with feelings that labor went ‘as expected’ (adjusted risk ratio for the direct effect 0.78, 95%CI [0.70–0.88]), length of labor was ‘acceptable’ (0.76[0.71–0.82]), ‘vaginal discomfort’ was absent (0.77[0.69–0.85]) and with lower global satisfaction (0.90[0.84–0.96]). Interventions and complications mediated between 6 and 35% of the total effect of cervical ripening on maternal experience. Compared to the dinoprostone insert, maternal experience was not significantly different with the other prostaglandins. The balloon catheter was associated with less pain.

Discussion

Cervical ripening was associated with a less positive experience of childbirth, whatever the method, only partly explained by interventions and complications of delivery.

Conclusion

Counselling and support of women requiring cervical ripening might be enhanced to improve the experience of IoL.

Peer Review reports

Tweetable abstract

In the French current practice, women’s experience of induction of labor was less positive with cervical ripening, whatever the method, compared to oxytocin infusion: results of the MEDIP population-based cohort of women with induction of labor.

Statement of significance

Problem

Experience of induction of labor (IoL) is rarely assessed according to the method and results found in RCT are not extrapolable in current practice.

What is already known

Negative experience of IoL can have short- and long-term effects on mother well-being and health and may be explained both by the methods and the outcomes of IoL.

What this paper adds

Using population-based data, experience of Iol was less positive with cervical ripening. Experience of IoL was not different according to the ripening method and was only partly explained by the interventions and complications.

Introduction

Women’s experience and satisfaction with childbirth is an important element for judging the quality of care in a maternity ward [1]. From 5 to 20% of women describe their experience of delivery as negative [2,3,4]. These negative experiences may have short- and long-term effects: impairment of the mother-child bond from the very start, postpartum depression, decisions to not become pregnant again, fear of delivery, and requests for a repeat cesarean for a subsequent pregnancy [5,6,7,8,9]. Generally, patients’ experience in hospitals is best when the medical outcomes of an intervention are both good and uncomplicated [10]. Women’s experience in childbirth is known to be worse when they have a cesarean delivery, especially when it is performed as an emergency [11, 12].

One of the most common interventions in obstetrics today is induction of labor (IoL). In most developed countries, one woman in five has labor induced [13,14,15]. The choice of the method depends in part on the clinical examination of cervical ripeness. Intravenous oxytocin infusion and amniotomy are recommended when the cervix is favorable, otherwise cervical ripening is necessary to increase the likelihood of successful induction [16]. Several methods of cervical ripening are commonly used because the data currently available do not justify to recommend one method over any other [17,18,19,20,21,22].

Most studies comparing methods of IoL have assessed their effectiveness and safety. Following a Delphi process, Dos Santos et al. [23] listed maternal experience of childbirth and satisfaction in the set of core outcomes that should routinely been assessed in studies dealing with IoL. A review of the literature has shown that only around 5% of the trials of induction report women’s experience of it [24]. The extrapolation of the results of trials is questionable because the populations included are highly selected and the women receive both standardized management and special attention because of their participation in the trial [25]. To our knowledge, no observational study has assessed women’s experience according to the method of induction in routine care with population-based data.

The objective of this study was to compare, in a population-based cohort of women who underwent induction of labor, the experience of delivery according to the method used, taking into account the mediating contribution of intervention and complication of delivery.

Material and methods

This was a comparative study using the data of the MEDIP (Methods of induction of labor and perinatal outcomes) prospective population-based cohort. The objective of the MEDIP study was to describe the practices of induction in France and to compare the effectiveness and safety of the different methods in current use [19]. This assessment of women’s experience was one of the planned secondary objectives of the study.

The cohort included all women who had labor induced from 17 November to 21 December 2015 in all maternity units belonging to 7 perinatal health networks (n = 94). These units accounted for one-sixth of the annual deliveries in France and were representative of the entire set of French maternity units [26]. Still birth and medically-indicated termination of pregnancy were exclusion criteria. A follow-up of two-months was performed.

Data were recorded prospectively. The midwife or obstetrician managing the woman informed the indication of IoL, the method used and the Bishop score at the onset of induction. The choice of method was based on each maternity ward’s habits or was left to the practitioner’s choice. Independent clinical research technicians recorded additional data from the woman’s medical records. Experience of induction was assessed with a self-administered questionnaire sent by mail or e-mail (three reminders) at 2 months postpartum.

The experience of IoL was first compared between women who underwent cervical ripening as first method of IoL and those who did not, i.e. those who received oxytocin infusion as first method (exposure/outcomes associations A). Secondarily, the experience of delivery was compared according to each method of cervical ripening (exposure/outcomes associations B). We compared the methods mainly used in the MEDIP cohort: vaginal dinoprostone pessary as a slow-release insert (as reference, because it was the method used most often), dinoprostone as a vaginal gel, misoprostol as a vaginal tablet and an intracervical balloon (Cook® balloon or Foley catheter). We excluded women who received PGE2 intracervical gel (n = 3) or intravenous PGE2 (n = 7) or membranes sweeping only (n = 1) because the number of women was too small to perform statistical comparisons for these methods (Fig. 1). In the MEDIP study, all methods of labor induction were used individually, with no combination of two methods simultaneously. Specific modes of usage of the methods in this cohort have previously been described [27].

Fig. 1
figure1

Flowchart of study population. Legend: Iol, induction of labor; PG, prostaglandins

For assessing women’s experience, a specific questionnaire was developed after a review of qualitative research on the topic by the study Scientific Committee, a multidisciplinary group of perinatal professionals, epidemiologists and user representatives [28,29,30]. We analysed eight self-administered questions about the course of labor and delivery, vaginal discomfort, maximum pain, global satisfaction and the likelihood that woman would choose the same method of induction again. Some categories were regrouped to obtain binary outcomes to study positive experience of childbirth (Additional file 1).

A directed acyclic graph (http://www.dagitty.net/) presented the assumed exposure-outcome pathway with confounding and mediators variables (Additional file 2). We considered that the outcomes of induction were mediators in the causal pathway between the induction method used and the experience of induction. For this reason, we did not adjust for these variables [31]. To take them into account, the outcomes of IoL were integrated as mediators. Mediation analysis decompose the total effect of the causal pathway between an exposure and an outcome into a direct and an indirect effect. The indirect effect estimated is the extent to which the method of labor induction affects women’s experience through the outcomes of delivery. The outcomes of induction were summarized in a composite variable called ‘delivery with intervention or complication’, that is, any combination of a cesarean or operative vaginal delivery, postpartum hemorrhage (total estimated blood loss ≥500 ml), severe perineal laceration or NICU admission. We adjusted for parity and history of C-section, body mass index, peridural analgesia, maternal age, medical indication and maternity status. We also adjusted for Bishop score when measuring the association between the experience of delivery according to each method of cervical ripening (B) but not for the first comparisons (A). In fact, adjusting for Bishop score may lead to overfitting because it is strongly correlated with the choice of performing cervical ripening or not. Interaction for parity and medical indication of IoL was tested.

Statistical analyses

Multivariable Poisson regression models were performed to obtain risk ratios. A robust variance was used to take the cluster effect into account. For the mediation analysis, we used the inverse odds weighting (IOW) method described by Nguyen et al. [32, 33] IOW is a weight-based approach that condenses the association between the exposure and the mediator into a weight. It is a stepwise process. First, we estimated for each woman the predictive odds of ‘undergoing cervical ripening’ due to a ‘delivery with intervention or complications’. The inverse of this predicted odds gives a weight. Secondarily, the direct effect of cervical ripening on maternal experience was estimated by using weighted Poisson regression. Then, the indirect effect was calculated by subtracting the direct from the total effect coefficients. The proportion mediated (PM) was calculated as the ratio of the total effect to the indirect effect [34]. Confidence intervals for indirect effect and PMs were obtained by bootstrapping. Complete case analyses were performed because outcome data were missing for fewer than 2% of the women who responded to the questionnaire. The statistical analyses were performed with Stata/SE software, version 15.0.

Results

Of the 3042 women included in the MEDIP cohort, 1453 (47.8%) responded to the self-administered questionnaire at 2 months postpartum. (49% by mail and 51% by e-mail). The respondents included a higher proportion of women who were nulliparous, older than 35 years, born in Europe, living with a partner, who belonged to higher socio-professional categories and who did not receive intracervical balloon for IoL. The response was not associated with more unfavorable outcomes or with medical interventions during delivery (Fig. 1).

Women’s characteristics of respondents and experience according to method of induction are described in Table 1 and Table 2. Compared with women receiving oxytocin (n = 541), those who underwent cervical ripening (n = 910) had a less positive experience of induction. After taking the confounding and mediating factors into account, cervical ripening was significantly associated with a lower risk of experiencing that ‘labor went quite normally’ (RR adjusted for direct effect, aRR 0.86, 95% CI 0.81–0.93), that ‘labor and delivery went as expected’ (direct aRR = 0.78, 95% CI 0.70–0.88 and aRR 0.88, 95% CI 0.79–0.98) and that the ‘length of labor was acceptable’ (direct aRR 0.76, 95% 0.71–0.82). Cervical ripening was also associated with less ‘absence of sensation of vaginal discomfort’ (direct aRR 0.77, 95% CI 0.69–0.85), maximum pain ‘less than 8/10’ (direct aRR 0.59, 95% CI 0.51–0.70), a poorer ‘global satisfaction’ (direct aRR 0.90, 95% CI 0.84–0.96), and less willingness to have another induction ‘by the same method’ (direct aRR 0.83, 95% CI 0.78–0.88). Tests of interaction for parity and medical indication for induction of labor were non-significant. Between 6 and 35% of the association between cervical ripening and experience was significantly mediated by the variable ‘delivery with intervention or complications’ (Table 3).

Table 1 Characteristics of study population according to the first method of labor induction
Table 2 Experience of labor induction according to the method used (cervical ripening versus oxytocin and/or amniotomy)
Table 3 Multivariable association between cervical ripening and maternal experience, mediated by interventions or complications of delivery

Comparing the dinoprostone insert (reference) to the other types of prostaglandins, the experience of IoL did not differ significantly for most items, except that more women who received the intravaginal misoprostol tablet did not experience vaginal discomfort (direct aRR 1.34, 95% 1.20–1.48) (Table 4). The intracervical balloon was associated with more frequent rating of maximum pain lower than 8/10 (direct aRR 1.78, 95% CI 1.20–2.65).

Table 4 Experience of induction of labor according to the different methods of cervical ripening

Discussion

Principal findings

Experience of induction of labor was less positive for women requiring cervical ripening. Women deplored a greater gap between what was expected and what was experienced, more unacceptable duration of labor, vaginal discomfort, intense pain, and insatisfaction with induction. Most of the experience was explained by the method and not by the interventions or complications of delivery. The women’s experience did not seem different between the prostaglandins but ripening with the balloon catheter seemed associated with less intense pain.

Strengths and limitations

This is to our knowledge the first study to examine specifically multiple domains of the experience of IoL associated with cervical ripening with population-based data while taking into account the mediating role of interventions and complications. The MEDIP study was specifically designed to study perinatal outcomes associated with the different methods of induction of labor in France [19, 26]. The prospective data collection about the course of induction ensured the quality of the information reported.

Our study had some limits. A non-validated questionnaire was used, because the existing scales did not appear appropriate for a specific evaluation of the experience of IoL. Since the MEDIP study was performed, the EXIT scale (Experience of induction tool) has been developed in Australia for this purpose, but it has never been validated in another population [35]. External validity is also questionable because the women included came from perinatal networks not randomly selected, although characteristics of maternity units participating in this large sample were comparable to those of all French maternity units [26]. There was also a selection bias of respondent women who were most frequently European and employed. This questionnaire was sent at 2 months because memories of facts immediately after delivery may be modified, due to tiredness or lack of time to integrate the course of events. Moreover, interviewing women during their stay in the maternity unit may have led the woman interviewed to provide information that she felt comfortable with the care providers. We cannot know whether the responses were biased toward women with less or worse positive experience or not. Nonetheless, we showed that the response was not associated with interventions or complications. Finally, a strong proportion of the experience was probably affected by the environment of birth, the specific organization of a maternity ward or the individual relation created between the woman and the provider supporting and caring for her [36, 37]. Such information might have been particularly relevant for comparison of different cervical ripening methods, for which the usage are heterogeneous and depend on maternity unit’s preferences [26].

Interpretation

These data about how women experience IoL according to the method used might be relevant for guiding the management of care. Qualitative studies have already shown that a negative experience of induction was associated with a lack of preparation and information about the benefits and risks of induction and its course, to the intensity of pain, the duration of the induction and to a poorer medical outcome, in particular, emergency cesarean delivery [36, 37]. These studies didn’t distinguished specifically women with cervical ripening. When comparing woman satisfaction between oxytocin alone and vaginal prostaglandins E2, a meta-analysis of Alfirevic et al. [16] previously found no difference. However, the three trials included had a different way of measuring maternal satisfaction and the studies were probably not representative of actual obstetric practice.

The less positive experience of childbirth with cervical ripening does not imply that oxytocin should be proposed whatever the degree of cervix immaturity. Indeed, cervical ripening is recommended in case of unfavourable cervix [38, 39]. However, it calls for stronger support and counselling. In France, most pregnant women attend antenatal birth classes, especially the nulliparous women, but the content of these classes are probably very heterogeneous. Antenatal education on what to expect after induction on labor according to the method should probably be enhanced [13]. Moreover, one-to-one support for management of pain, which is not usual in French practices would certainly be good for improving maternal experience [37].

Our results also raise questions, as the number of elective IoL might be increased in the coming years. Indeed, recent data have demonstrated better perinatal outcomes with elective induction of labor at term, regardless of cervical status [40,41,42]. In the ARRIVE trial comparing induction of labor with expectant management among 6000 low-risk nulliparous women at 39 weeks of gestation, induction of labor resulted in a better global experience and less pain [43]. Results were not stratified according to the method of induction. One limitation is that the experience of women who agreed to participate to such trial may not be representative of that of women in general population. They volunteered to participate and may have been more inclined to experience their induction positively whatever the method used. In the review of observational study comparing induction of labor with expectant management, women’s experience was not evaluated [42]. Our results can not imply that women who had unfavourable cervix expectantly managed instead of being induced would have had a better experience. However, in the absence of a medical indication, waiting for the cervix to be more favourable may be an alternative to improve maternal experience.

The few studies comparing the experience of different methods of cervical ripening also found greater discomfort and stronger pain during induction by prostaglandins compared with the balloon, but overall global satisfaction did not differ [44, 45]. This may be explained by the fact that the balloon appears to have a mechanical ripening action but not contraction-inducing effect that may be less painful. These results merit further exploration in view of the small number of women induced with the balloon included in these studies as in our study.

Conclusion

In current practice, cervical ripening was associated with a less positive experience of Iol, the major part of it was not explained by the interventions and complications of delivery. Counselling and support of women requiring cervical ripening might improve the experience of induction of labor. Further data about experience according to the method of cervical ripening are necessary.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

Iol:

Induction of labor

BMI:

Body mass index

CS:

Cesarean section;

PPH:

Postpartum hemorrhage

NICU:

Neonatal intensive care unit

RCT:

Randomized controlled trial

References

  1. 1.

    Goberna-Tricas J, Banús-Giménez MR, Palacio-Tauste A, Linares-Sancho S. Satisfaction with pregnancy and birth services: the quality of maternity care services as experienced by women. Midwifery. 2011;27(6):e231–7. https://0-doi-org.brum.beds.ac.uk/10.1016/j.midw.2010.10.004.

    Article  PubMed  Google Scholar 

  2. 2.

    Henriksen L, Grimsrud E, Schei B, Lukasse M, Bidens study group. Factors related to a negative birth experience - a mixed methods study. Midwifery. 2017;51:33–9. https://0-doi-org.brum.beds.ac.uk/10.1016/j.midw.2017.05.004.

    Article  PubMed  Google Scholar 

  3. 3.

    Smarandache A, Kim THM, Bohr Y, Tamim H. Predictors of a negative labour and birth experience based on a national survey of Canadian women. BMC Pregnancy Childbirth. 2016;16(1):114. https://0-doi-org.brum.beds.ac.uk/10.1186/s12884-016-0903-2.

    Article  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Waldenström U, Rudman A, Hildingsson I. Intrapartum and postpartum care in Sweden: women’s opinions and risk factors for not being satisfied. Acta Obstet Gynecol Scand. 2006;85(5):551–60. https://0-doi-org.brum.beds.ac.uk/10.1080/00016340500345378.

    Article  PubMed  Google Scholar 

  5. 5.

    Gottvall K, Waldenström U. Does a traumatic birth experience have an impact on future reproduction? BJOG Int J Obstet Gynaecol. 2002;109(3):254–60. https://0-doi-org.brum.beds.ac.uk/10.1111/j.1471-0528.2002.01200.x.

    Article  Google Scholar 

  6. 6.

    Størksen HT, Garthus-Niegel S, Vangen S, Eberhard-Gran M. The impact of previous birth experiences on maternal fear of childbirth. Acta Obstet Gynecol Scand. 2013;92(3):318–24. https://0-doi-org.brum.beds.ac.uk/10.1111/aogs.12072.

    Article  PubMed  Google Scholar 

  7. 7.

    Bell AF, Rubin LH, Davis JM, Golding J, Adejumo OA, Carter CS. The birth experience and subsequent maternal caregiving attitudes and behavior: a birth cohort study. Arch Womens Ment Health. 2019;22(5):613–20. https://0-doi-org.brum.beds.ac.uk/10.1007/s00737-018-0921-3.

    CAS  Article  PubMed  Google Scholar 

  8. 8.

    Bell AF, Andersson E. The birth experience and women’s postnatal depression: a systematic review. Midwifery. 2016;39:112–23. https://0-doi-org.brum.beds.ac.uk/10.1016/j.midw.2016.04.014.

    Article  PubMed  Google Scholar 

  9. 9.

    Hildingsson I, Rådestad I, Rubertsson C, Waldenström U. Few women wish to be delivered by caesarean section. BJOG Int J Obstet Gynaecol. 2002;109(6):618–23. https://0-doi-org.brum.beds.ac.uk/10.1111/j.1471-0528.2002.01393.x.

    Article  Google Scholar 

  10. 10.

    Doyle C, Lennox L, Bell D. A systematic review of evidence on the links between patient experience and clinical safety and effectiveness. BMJ Open. 2013;3(1):e001570. https://0-doi-org.brum.beds.ac.uk/10.1136/bmjopen-2012-001570.

    Article  PubMed  PubMed Central  Google Scholar 

  11. 11.

    Handelzalts JE, Waldman Peyser A, Krissi H, Levy S, Wiznitzer A, Peled Y. Indications for emergency intervention, mode of delivery, and the childbirth experience. PLoS One. 2017;12(1):e0169132. https://0-doi-org.brum.beds.ac.uk/10.1371/journal.pone.0169132.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  12. 12.

    Carquillat P, Boulvain M, Guittier M-J. How does delivery method influence factors that contribute to women’s childbirth experiences? Midwifery. 2016;43:21–8. https://0-doi-org.brum.beds.ac.uk/10.1016/j.midw.2016.10.002.

    Article  PubMed  Google Scholar 

  13. 13.

    Blondel B, Coulm B, Bonnet C, Goffinet F, le Ray C, National Coordination Group of the National Perinatal Surveys. Trends in perinatal health in metropolitan France from 1995 to 2016: results from the French National Perinatal Surveys. J Gynecol Obstet Hum Reprod. 2017;46(10):701–13. https://0-doi-org.brum.beds.ac.uk/10.1016/j.jogoh.2017.09.002.

    CAS  Article  PubMed  Google Scholar 

  14. 14.

    Martin JA, Hamilton BE, Osterman MJK, Driscoll AK, Mathews TJ. Births: final data for 2015. Natl Vital Stat Rep Cent Dis Control Prev Natl Cent Health Stat Natl Vital Stat Syst. 2017;66(1).

  15. 15.

    European Perinatal Health Report 2010 - Euro-Peristat. https://www.europeristat.com/reports/european-perinatal-health-report-2010.html.

  16. 16.

    Alfirevic Z, Kelly AJ, Dowswell T. Intravenous oxytocin alone for cervical ripening and induction of labour. Cochrane Database Syst Rev. 2009:CD003246. https://0-doi-org.brum.beds.ac.uk/10.1002/14651858.CD003246.pub2.

  17. 17.

    Alfirevic Z, Keeney E, Dowswell T, Welton NJ, Dias S, Jones LV, et al. Labour induction with prostaglandins: a systematic review and network meta-analysis. BMJ. 2015;350(feb05 10):h217. https://0-doi-org.brum.beds.ac.uk/10.1136/bmj.h217.

    Article  PubMed  PubMed Central  Google Scholar 

  18. 18.

    Chen W, Xue J, Peprah MK, Wen SW, Walker M, Gao Y, et al. A systematic review and network meta-analysis comparing the use of Foley catheters, misoprostol, and dinoprostone for cervical ripening in the induction of labour. BJOG Int J Obstet Gynaecol. 2016;123(3):346–54. https://0-doi-org.brum.beds.ac.uk/10.1111/1471-0528.13456.

    CAS  Article  Google Scholar 

  19. 19.

    Blanc-Petitjean P, Carbonne B, Deneux-Tharaux C, Salomé M, Goffinet F, le Ray C, et al. Comparison of effectiveness and safety of cervical ripening methods for induction of labour: a population-based study using coarsened exact matching. Paediatr Perinat Epidemiol. 2019;33(5):313–22. https://0-doi-org.brum.beds.ac.uk/10.1111/ppe.12569.

    Article  PubMed  Google Scholar 

  20. 20.

    De Vivo V, et al. Early amniotomy after cervical ripening for induction of labor: a systematic review and meta-analysis of randomized controlled trials. Am J Obstet Gynecol. 2020;222(4):320–9. https://0-doi-org.brum.beds.ac.uk/10.1016/j.ajog.2019.07.049.

    CAS  Article  PubMed  Google Scholar 

  21. 21.

    Mozurkewich EL, Chilimigras JL, Berman DR, Perni UC, Romero VC, King VJ, et al. Methods of induction of labour: a systematic review. BMC Pregnancy Childbirth. 2011;11(1):84. https://0-doi-org.brum.beds.ac.uk/10.1186/1471-2393-11-84.

    Article  PubMed  PubMed Central  Google Scholar 

  22. 22.

    Di Mascio D, et al. Maternal and neonatal outcomes of pregnancies complicated by late fetal growth restriction undergoing induction of labor with dinoprostone compared with cervical balloon: a retrospective, international study. Acta Obstet Gynecol Scand. 2021;100(7):1313–21. https://0-doi-org.brum.beds.ac.uk/10.1111/aogs.14135.

    CAS  Article  PubMed  Google Scholar 

  23. 23.

    Dos Santos F, Drymiotou S, Antequera Martin A, Mol BW, Gale C, Devane D, et al. Development of a core outcome set for trials on induction of labour: an international multistakeholder Delphi study. BJOG Int J Obstet Gynaecol. 2018;125(13):1673–80. https://0-doi-org.brum.beds.ac.uk/10.1111/1471-0528.15397.

    Article  Google Scholar 

  24. 24.

    Medley N, et al. Outcomes reported in trials of methods for the induction of labour. Trials. 2015;16:P4 1745–6215-16-S1-P4.

    Article  Google Scholar 

  25. 25.

    Rothwell PM. External validity of randomised controlled trials: ‘to whom do the results of this trial apply?’. Lancet Lond Engl. 2005;365(9453):82–93. https://0-doi-org.brum.beds.ac.uk/10.1016/S0140-6736(04)17670-8.

    Article  Google Scholar 

  26. 26.

    Blanc-Petitjean P, Salomé M, Dupont C, Crenn-Hebert C, Gaudineau A, Perrotte F, et al. Labour induction practices in France: a population-based declarative survey in 94 maternity units. J Gynecol Obstet Hum Reprod. 2018;47(2):57–62. https://0-doi-org.brum.beds.ac.uk/10.1016/j.jogoh.2017.11.006.

    CAS  Article  PubMed  Google Scholar 

  27. 27.

    Blanc-Petitjean P, et al. Overview of induction of labor practices in France. Gynecol Obstet Fertil Senol. 2019;47:555–61.

    CAS  PubMed  Google Scholar 

  28. 28.

    Jay A, Thomas H, Brooks F. In labor or in limbo? The experiences of women undergoing induction of labor in hospital: Findings of a qualitative study. Birth Berkeley Calif. 2018;45:64–70.

    Article  Google Scholar 

  29. 29.

    Shetty A, Burt R, Rice P, Templeton A. Women’s perceptions, expectations and satisfaction with induced labour--a questionnaire-based study. Eur J Obstet Gynecol Reprod Biol. 2005;123(1):56–61. https://0-doi-org.brum.beds.ac.uk/10.1016/j.ejogrb.2005.03.004.

    Article  PubMed  Google Scholar 

  30. 30.

    Henderson J, Redshaw M. Women’s experience of induction of labor: a mixed methods study. Acta Obstet Gynecol Scand. 2013;92(10):1159–67. https://0-doi-org.brum.beds.ac.uk/10.1111/aogs.12211.

    Article  PubMed  Google Scholar 

  31. 31.

    Ananth CV, Schisterman EF. Confounding, causality, and confusion: the role of intermediate variables in interpreting observational studies in obstetrics. Am J Obstet Gynecol. 2017;217(2):167–75. https://0-doi-org.brum.beds.ac.uk/10.1016/j.ajog.2017.04.016.

    Article  PubMed  PubMed Central  Google Scholar 

  32. 32.

    Nguyen QC, Osypuk TL, Schmidt NM, Glymour MM, Tchetgen Tchetgen EJ. Practical guidance for conducting mediation analysis with multiple mediators using inverse odds ratio weighting. Am J Epidemiol. 2015;181(5):349–56. https://0-doi-org.brum.beds.ac.uk/10.1093/aje/kwu278.

    Article  PubMed  PubMed Central  Google Scholar 

  33. 33.

    Tchetgen Tchetgen EJ. Inverse odds ratio-weighted estimation for causal mediation analysis. Stat Med. 2013;32(26):4567–80. https://0-doi-org.brum.beds.ac.uk/10.1002/sim.5864.

    Article  PubMed  PubMed Central  Google Scholar 

  34. 34.

    Ananth CV. Proportion mediated in a causal mediation analysis: how useful is this measure? BJOG Int J Obstet Gynaecol. 2019;126:983.

    CAS  Google Scholar 

  35. 35.

    Beckmann M, Thompson R, Miller Y, Prosser SJ, Flenady V, Kumar S. Measuring women’s experience of induction of labor using prostaglandin vaginal gel. Eur J Obstet Gynecol Reprod Biol. 2017;210:189–95. https://0-doi-org.brum.beds.ac.uk/10.1016/j.ejogrb.2016.12.032.

    CAS  Article  PubMed  Google Scholar 

  36. 36.

    Akuamoah-Boateng J, Spencer R. Woman-centered care: Women’s experiences and perceptions of induction of labor for uncomplicated post-term pregnancy: a systematic review of qualitative evidence. Midwifery. 2018;67:46–56. https://0-doi-org.brum.beds.ac.uk/10.1016/j.midw.2018.08.018.

    Article  PubMed  Google Scholar 

  37. 37.

    Coates R, Cupples G, Scamell A, McCourt C. Women’s experiences of induction of labour: qualitative systematic review and thematic synthesis. Midwifery. 2019;69:17–28. https://0-doi-org.brum.beds.ac.uk/10.1016/j.midw.2018.10.013.

    Article  PubMed  Google Scholar 

  38. 38.

    ACOG Practice Bulletin No. 107. Induction of labor. Obstet Gynecol. 2009;114(386–397).

  39. 39.

    Induction of Labour. Royal College of Obstetricians and Gynaecologists https://www.rcog.org.uk/en/guidelines-research-services/guidelines/induction-of-labour/.

  40. 40.

    Bernardes TP, Broekhuijsen K, Koopmans CM, Boers KE, van Wyk L, Tajik P, et al. Caesarean section rates and adverse neonatal outcomes after induction of labour versus expectant management in women with an unripe cervix: a secondary analysis of the HYPITAT and DIGITAT trials. BJOG Int J Obstet Gynaecol. 2016;123(9):1501–8. https://0-doi-org.brum.beds.ac.uk/10.1111/1471-0528.14028.

    CAS  Article  Google Scholar 

  41. 41.

    Miller NR, Cypher RL, Foglia LM, Pates JA, Nielsen PE. Elective induction of labor compared with expectant Management of Nulliparous Women at 39 weeks of gestation: a randomized controlled trial. Obstet Gynecol. 2015;126(6):1258–64. https://0-doi-org.brum.beds.ac.uk/10.1097/AOG.0000000000001154.

    Article  PubMed  Google Scholar 

  42. 42.

    Grobman WA, Caughey AB. Elective induction of labor at 39 weeks compared with expectant management: a meta-analysis of cohort studies. Am J Obstet Gynecol. 2019;221(4):304–10. https://0-doi-org.brum.beds.ac.uk/10.1016/j.ajog.2019.02.046.

    Article  PubMed  Google Scholar 

  43. 43.

    Grobman WA, Rice MM, Reddy UM, Tita ATN, Silver RM, Mallett G, et al. Labor induction versus expectant Management in low-Risk Nulliparous Women. N Engl J Med. 2018;379(6):513–23. https://0-doi-org.brum.beds.ac.uk/10.1056/NEJMoa1800566.

    Article  PubMed  PubMed Central  Google Scholar 

  44. 44.

    Pennell CE, Henderson JJ, O’Neill MJ, McCleery S, Doherty DA, Dickinson JE. Induction of labour in nulliparous women with an unfavourable cervix: a randomised controlled trial comparing double and single balloon catheters and PGE2 gel. BJOG Int J Obstet Gynaecol. 2009;116(11):1443–52. https://0-doi-org.brum.beds.ac.uk/10.1111/j.1471-0528.2009.02279.x.

    CAS  Article  Google Scholar 

  45. 45.

    Henry A, Madan A, Reid R, Tracy SK, Austin K, Welsh A, et al. Outpatient Foley catheter versus inpatient prostaglandin E2 gel for induction of labour: a randomised trial. BMC Pregnancy Childbirth. 2013;13(1):25. https://0-doi-org.brum.beds.ac.uk/10.1186/1471-2393-13-25.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The MEDIP study was conducted by Assistance Public-Hôpitaux de Paris (Département de la recherche Clinique et du développement). The authors thank all the members of the MEDIP study scientific committee: Catherine Crenn-Hebert, Adrien Gaudineau, Frédérique Perrotte, Pierre Raynal, Elodie Clouqueur, Gaël Beucher, Catherine Deneux-Tharaux, Pierre-Yves Ancel, and all the local investigators for their contributions to the MEDIP study. The authors also thank the URC-CIC Paris Descartes Necker/Cochin (Laurence Lecomte, Isabelle April and Marina Salomé) for setting up and monitoring the MEDIP study, all the women who agreed to participate in it and the midwives who recruited and included them.

Funding

Data comes from the MEDIP study, funded by the national agency for drug safety and health products (ANSM) as part of a call for research projects (No. AAP-2014-030). Pauline Blanc-Petitjean’s PhD research was funded by a research grant by Assistance Publique-Hôpitaux de Paris.

Author information

Affiliations

Authors

Consortia

Contributions

CLR and FG conceived the study. PBP, CLR, CD, MS, BC and FG contributed to its design, conducted the analyses, performed the study, drafted the original manuscript, reviewed and revised the manuscript. All authors approved the final manuscript as submitted.

Corresponding author

Correspondence to Pauline Blanc-Petitjean.

Ethics declarations

Ethics approval and consent to participate

The MEDIP protocol was registered in the ClinicalTrial database (22/06/2015, No. NCT02477085) and approved by the Patient Protection Committee of Ile de France 1 in May 2015 (CPPIDF1–2015-May-DAP 21bis). The CCTIRS (No.15.609) and the CNIL (MMS/VCS/AR1510301) authorized the use of the data for this study. Informed consent was obtained from all women included in the cohort. All methods were carried out in accordance with relevant guidelines and regulations.

Consent for publication

All authors have read and approved the content, and agree to submit the manuscript for consideration for publication in your journal.

Competing interests

The authors have no competing interests or other interests that might be perceived to influence the results and/or discussion reported in this paper.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Additional file 1: Table.

Items of the self-administered questionnaire evaluating the positive experience of induction of labor.

Additional file 2: Figure.

Directed acyclic graph for the association between the method of labor induction and maternal experience. Legend: DAG created with the web-based application DAGitty (http://www.dagitty.net/). CS: caesarean section, BMI: body mass index.

Additional file 3: Table.

Characteristics and major outcomes of women who did and did not respond to the questionnaire.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Blanc-Petitjean, P., Dupont, C., Carbonne, B. et al. Methods of induction of labor and women’s experience: a population-based cohort study with mediation analyses. BMC Pregnancy Childbirth 21, 621 (2021). https://0-doi-org.brum.beds.ac.uk/10.1186/s12884-021-04076-x

Download citation

Keywords

  • Induction of labor
  • Cervical ripening
  • Maternal experience, midwifery research, causal mediation analysis