The role of maternal homocysteine concentration in placenta-mediated complications: findings from the Ottawa and Kingston birth cohort

Table 5 Multivariable logistic regression analyses examining the moderating effect of high-risk pregnancy ^a on the association between homocysteine and placenta-mediated complications, n = 7587

Outcome variable	Odds ratio (95% CI) for 5 μmol/L increase ^b		p-value ^c
Outcome variable	High-risk	Low-risk	p-value ^c
Any placenta-mediated complication (759 events ^d)	2.368 (1.239, 4.525)	1.595 (1.176, 2.163)	0.2714
SGA (512 events ^d)	2.474 (1.050, 5.828)	1.821 (1.276, 2.597)	0.5081
Preeclampsia (227 events)	2.839 (1.187, 6.792)	1.308 (0.743, 2.302)	0.1351

^aHomocysteine*High-risk pregnancy (Factor + higher order factors)
^bModel adjusted for maternal age, race, education, parity, smoking, hormonal birth control, folic acid supplementation, serum folate, gestational age at blood work
^cWald test of most meaningful hypotheses, pooled across multiple imputation datasets
^d79 Missing outcome values imputed

ISSN: 1471-2393