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Table 1 Phenotype analysis of different immune cell population in healthy pregnant and in non-pregnant women

From: The importance of the PD-1/PD-L1 pathway at the maternal-fetal interface

 

Non-pregnant PBMC

1 st -trimester PBMC

1 st -trimester DIC

p-value

CD8+ T cells in CD3+ cells

33.21 ± 7.27

34.00 ± 6.90

56.60 ± 15.07*

* < 0.01

CD4+ T cells in CD3+ cells

57.28 ± 10.10

52.51 ± 8.96

31.02 ± 16.70*

* < 0.01

Treg cells

2.19 ± 0.77

1.71 ± 0.79

2.95 ± 3.44

NS

CD56+NK cells

18.44 ± 5.61

13.61 ± 5.17

48.45 ± 22.36*

* < 0.01

CD56dim NK cells

16.43 ± 5.23

11.99 ± 4,28

27.30 ± 14.14*

* < 0.01

CD56bright NK cells

2.04 ± 1.12

1.42 ± 1.03

21.17 ± 12.93*

* < 0.01

NKT-like cells

3.55 ± 3.37

3.74 ± 2.15

4.46 ± 3.67

NS

CD8+ T cells in PD-1+ CD3+ cells

41.59 ± 10.23**

31.48 ± 9.09

62.52 ± 15.19*

* < 0.01

** < 0.03

CD4+ T cells in PD-1+ CD3+ cells

45.06 ± 13.11

47.39 ± 15.24

28.06 ± 15.30*

* <0.02

  1. Statistical comparisons were made by Student’s t-test between non-regnant PBMC vs. 1st-trimester PBMC group and 1st-trimester PBMC vs. 1st-trimester DIC group. The results were expressed as the mean value ± standard deviation (SD). Differences were considered significant when the value of p was equal to or less than 0.05. Non-significant (NS)
  2. *significantly differ from 1st trimester PBMC, **significantly differ from 1st trimester PBMC