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Table 4 Effect of mode of conception on maternal/perinatal complications and adverse outcomes

From: Complications and adverse outcomes in pregnancy and childbirth among women who conceived by assisted reproductive technologies: a nationwide birth cohort study of Japan environment and children’s study

 

Logistic regression with case-wise deletion of missing data

Multiple imputation

Crude OR

95% CI

aOR

95% CI

aOR

95% CI

OI without ART

 Maternal outcomesa

  Placenta previa

0.76

0.43

1.31

0.62

0.35

1.09

0.85

0.55

1.32

  Placental abruption

1.33

0.82

2.18

1.33

0.80

2.19

1.13

0.71

1.81

  MAP

1.46

0.74

2.86

1.46

0.73

2.91

1.23

0.62

2.45

  Gestational diabetes

1.40

1.16

1.69

0.97

0.80

1.19

0.98

0.81

1.18

  PIH

1.55

1.30

1.84

1.10

0.91

1.32

1.11

0.94

1.31

  Cesarean section

1.41

1.29

1.53

1.12

0.99

1.26

1.08

0.97

1.21

  Blood transfusion

1.35

0.83

2.21

1.03

0.62

1.71

0.94

0.59

1.5

  ICU admission

2.16

1.04

4.46

1.29

0.60

2.79

1.07

0.49

2.3

 Fetal/neonatal outcomesb

  Preterm birth

1.93

1.71

2.18

1.05

0.09

1.24

1.01

0.86

1.18

  Low birth weight

1.88

1.70

2.07

1.04

0.93

1.19

1.04

0.93

1.17

Conventional IVT-ET

 Maternal outcomesa

  Placenta previa

4.68

3.22

6.82

2.90

1.94

4.34

2.86

1.99

4.12

  Placental abruption

1.03

0.43

2.50

0.91

0.37

2.26

1.08

0.53

2.22

  MAP

6.88

4.09

11.58

6.85

3.88

12.13

5.74

2.93

11.2

  Gestational diabetes

1.88

1.45

2.45

0.99

0.75

1.31

1.13

0.88

1.45

  PIH

2.43

1.94

3.05

1.40

1.10

1.78

1.41

1.13

1.76

  Cesarean section

2.69

2.39

3.02

1.85

1.58

2.17

1.9

1.64

2.19

  Blood transfusion

6.18

4.20

9.09

3.85

2.52

5.88

3.57

2.45

5.21

  ICU admission

4.98

2.30

10.80

2.58

1.11

6.01

2.04

0.89

4.66

 Fetal/neonatal outcomesb

  Preterm birth

2.59

2.18

3.08

1.42

1.13

1.78

1.36

1.11

1.66

  Low birth weight

1.90

1.63

2.22

0.94

0.76

1.15

1.01

0.85

1.2

ICSI

 Maternal outcomesa

  Placenta previa

3.37

2.22

5.11

2.01

1.29

3.13

2.02

1.36

3.01

  Placental abruption

2.44

1.40

4.26

2.16

1.20

3.88

2.35

1.44

3.82

  MAP

7.41

4.57

12.00

7.81

4.56

13.38

7.86

4.56

13.5

  Gestational diabetes

1.85

1.43

2.38

0.97

0.74

1.27

1.06

0.83

1.35

  PIH

2.16

1.73

2.71

1.25

0.98

1.60

1.34

1.07

1.67

  Cesarean section

2.75

2.46

3.07

1.89

1.62

2.19

1.82

1.59

2.09

  Blood transfusion

5.98

4.11

8.69

3.76

2.49

5.66

3.43

2.37

4.96

  ICU admission

7.11

3.78

13.36

3.45

1.68

7.06

3.87

2.07

7.24

 Fetal/neonatal outcomesb

  Preterm birth

2.33

1.96

2.77

1.31

1.05

1.64

1.21

0.99

1.47

  Low birth weight

1.78

1.53

2.07

0.87

0.72

1.06

0.89

0.74

1.06

  1. aOR adjusted odds ratio, ART assisted reproductive technologies, CI confidence intervals, ICSI intracytoplasmic sperm injection, ICU intensive care unit, IVF-ET in vitro fertilization and embryo transfer, MAP morbidly adherent placenta, OI ovulation induction, OR odds ratio, PIH pregnancy-induced hypertension
  2. Women who conceived naturally served as the reference group
  3. Adjusted odds ratios were calculated by controlling for maternal age, maternal body mass index (BMI) before pregnancy, maternal height, maternal weight before delivery, parity, prior cesarean section, pre-existing maternal conditions, multiple pregnancies, fetal presentation, folic acid supplementation, maternal smoking during pregnancy, maternal drinking during pregnancy, maternal educational level, paternal smoking, paternal educational level, and household income
  4. alogistic regression; bgeneralized estimating equations (GEE)
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BMC Pregnancy and Childbirth

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