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Table 1 Demographic and virological characteristics in 727 HBsAg-positive pregnant women and women with different reproductive histories

From: Comparison of hepatitis B viral loads and viral antigen levels in child-bearing age women with and without pregnancy

  Total
(n = 727)
Nullipara
(n = 158)
Pregnancy
(n = 214)
Puerperant, 7–12 months postpartum (n = 170) Puerperant, 2–5 years postpartum (n = 185) p
Age (year) 26.0 (22.0–32.4) 25.0 (22.0–30.0) 25.3 (22.7–30.2) 26.2 (23.6–31.5)a 29.3 (24.0–32.4)a, b < 0.05
Positive HBeAg (%) 240 (33.0) 54 (34.2) 72 (33.6%) 60 (35.3) 54 (29.2) 0.624
HBV DNA, log IU/ml (min-max) 3.1 (1.4–9.2) 3.0 (1.4–9.0) 3.1 (1.6–8.9) 3.2 (1.5–9.2) 3.1 (1.4–9.1) 0.543
HBsAg, log IU/ml (min-max) 3.7 (0.9–5.9) 3.4 (0.9–5.0) 3.7 (0.9–5.9) 3.8 (1.0–5.4) 3.5 (1.3–5.4) 0.072
Genotypec
 B (%) 303 (44.2) 59 (44.4) 70 (33.5)d 77 (46.7) 97 (54.2) 0.001
 C (%) 383 (55.8) 74 (55.6) 139 (66.5)d 88 (53.3) 82 (45.8)
  1. The units of numbers in the parentheses are indicated in the first column
  2. HBeAg hepatitis B e antigen, HBsAg hepatitis B surface antigen, HBV hepatitis B virus
  3. ap < 0.05 compared with the age of nulliparas and pregnant women
  4. bp < 0.05 compared with puerperant women 7–12 months postpartum
  5. cHBV genotype was not determined in 38 women because of failure in the amplification of HBV DNA, including 24 nulliparas, 4 pregnant women, 5 puerperants 7–12 months postpartum and 5 puerperants 2–5 years postpartum. Additionally, there were two women infected with genotype D and one woman infected with genotype G. Since the numbers for genotypes D and G were too low to be meaningfully compared, we did not include these three women in the analysis
  6. dp = 0.043, 0.010, and < 0.001 compared with the frequencies of genotypes B and C in nullipara group, puerperant 7–12 months postpartum and puerperant 2–5 years postpartum respectively. The differences between any other groups had no statistical significance (all p > 0.05)