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Table 4 Population pharmacokinetic model parameters – mean ± SE

From: A randomized trial comparing the pharmacology of magnesium sulfate when used to treat severe preeclampsia with serial intravenous boluses versus a continuous intravenous infusion

Clearance (mL/min)

56.3 ± 12.7

Volume of distribution (L)

65.3 ± 13.1

Baseline Mg concentration

(mmol/L)

0.925 ± 0.037

(mg/dL)

2.25 ± 0.09

Weight effect on volume exponential (θ1)

−0.426 ± 0.196

Serum creatinine effect on exponential (θ1)

0.553 ± 0.138

Residual variability

0.0387 ± 0.0013