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Table 4 Results of the univariate analyses

From: Prediction of pre-eclampsia and its subtypes in high-risk cohort: hyperglycosylated human chorionic gonadotropin in multivariate models

Variable

Participants

Median (IQR) / Mean (SD)

OR (95% CI)

p-value

 

PE, n

No PE, n

PE

No PE

  

hCG-h MoM

34

223

0.27 (0.11–0.61)

0.30 (0.15–055)

0.98 (0.49–1.97)

0.958

%hCG-h MoM

34

223

0.77 (0.64–1.24)

0.99 (0.71–1.45)

0.55 (0.26–1.14)

0.107

hCGβ MoM

34

223

0.60 (0.35–0.89)

0.56 (0.35–0.91)

1.21 (0.70–2.10)

0.503

PAPP-A MoM

34

222

0.69 (0.45–0.92)

0.84 (0.52–1.26)

0.50 (0.24–1.05)

0.069

PlGF MoM

34

222

0.82 (0.65–1.06)

0.99 (0.81–1.22)

0.32 (0.10–1.00)

0.051

Uta-PI MoM

29

186

1.15 (0.83–1.25)

0.92 (0.71–1.12)

3.81 (1.12–12.95)

0.032

MAPa

34

211

102.1 (10.9)

94.7 (14.4)

1.05 (1.02–1.09)

0.001

Variable

EOPE, n

No EOPE, n

EOPE

No EOPE

OR (95% CI)

p-value

hCG-h MoM

9

248

0.61 (0.23–0.75)

0.29 (0.14–0.53)

0.65 (1.61–3.96)

0.304

%hCG-h MoM

9

248

1.32 (1.15–1.50)

0.92 (0.68–1.39)

1.58 (0.57–4.39)

0.381

hCGβ MoM

9

248

0.84 (0.61–1.04)

0.56 (0.34–0.91)

0.61 (1.41–3.26)

0.417

PAPP-A MoM

9

247

0.56 (0.50–0.85)

0.83 (0.51–1.21)

0.11 (0.46–2.01)

0.305

PlGF MoM

9

247

0.63 (0.47–0.73)

0.98 (0.80–1.22)

< 0.001 (< 0.001–0.04)

< 0.001

Uta-PI MoM

6

209

1.17 (0.97–1.25)

0.93 (0.73–1.14)

0.59 (5.56–52.2)

0.134

MAPa

9

236

104.3 (15.0)

95.4 (11.5)

1.06 (1.01–1.12)

0.028

Variable

LOPE, n

No LOPE, n

LOPE

No LOPE

OR (95% CI)

p-value

hCG-h MoM

25

232

0.20 (0.10–0.33)

0.30 (0.15–0.57)

0.26 (0.70–1.87)

0.478

%hCG-h MoM

25

232

0.76 (0.64–0.89)

1.02 (0.71–1.46)

0.30 (0.11–0.81)

0.018

hCGβ MoM

25

232

0.54 (0.31–0.79)

0.57 (0.35–0.91)

0.56 (1.09–2.13)

0.796

PAPP-A MoM

25

231

0.72 (0.43–0.95)

0.84 (0.51–1.22)

0.23 (0.54–1.24)

0.144

PlGF MoM

25

231

0.86 (0.80–1.18)

0.98 (0.80–1.21)

0.91 (0.34–2.41)

0.846

Uta-PI MoM

23

192

1.06 (0.78–1.33)

0.94 (0.72–1.13)

2.96 (0.78–11.23)

0.110

MAPa

25

220

101.3 (14.5)

95.0 (11.2)

1.04 (1.01–1.08)

0.013

Variable

Severe PE, n

No Severe PE, n

Severe PE

No Severe PE

OR (95% CI)

p-value

hCG-h MoM

17

240

0.47 (0.12–0.75)

0.30 (0.15–0.53)

1.63 (0.82–3.27)

0.165

%hCG-h MoM

17

240

0.90 (0.64–1.50)

0.95 (0.69–1.39)

0.94 (0.39–2.25)

0.885

hCGβ MoM

17

240

0.85 (0.35–1.13)

0.56 (0.35–0.90)

1.78 (1.01–3.16)

0.048

PAPP-A MoM

17

239

0.77 (0.45–1.08)

0.83 (0.51–1.21)

0.81 (0.37–1.80)

0.612

PlGF MoM

17

239

0.80 (0.61–0.83)

0.98 (0.80–1.22)

0.11 (0.02–0.69)

0.018

Uta-PI MoM

17

239

1.21 (0.96–1.43)

0.93 (0.73–1.13)

6.97 (1.4–34.2)

0.017

MAPa

17

228

105.8 (16.0)

94.9 (11.0)

1.08 (1.03–1.12)

0.001

Variable

Non-severe PE, n

No Non-severe PE, n

Non-severe PE

No Non-severe PE

OR (95% CI)

p-value

hCG-h MoM

17

240

0.15 (0.30–0.57)

0.22 (0.10–0.33)

0.22 (0.03–1.55)

0.127

%hCG-h MoM

17

240

0.78 (0.68–0.89)

0.98 (0.69–1.46)

0.28 (0.09–0.95)

0.041

hCGβ MoM

17

240

0.56 (0.37–0.75)

0.57 (0.35–0.92)

0.41 (0.10–1.63)

0.207

PAPP-A MoM

17

239

0.55 (0.49–0.90)

0.84 (0.51–1.26)

0.25 (0.07–0.94)

0.041

PlGF MoM

17

239

0.86 (0.73–1.08)

0.98 (0.80–1.21)

0.76 (0.22–2.65)

0.663

Uta-PI MoM

15

200

1.02 (0.82–1.21)

0.94 (0.73–1.14)

1.57 (0.30–8.31)

0.596

MAPa

17

228

98.3 (12.0)

95.5 (11.7)

1.02 (0.98–1.06)

0.336

  1. amean and SD
  2. Binary logistic regression was used to evaluate the association of measured variables to pre-eclampsia and its subtypes
  3. IQR interquartile range; SD standard deviation; CI confidence interval; PE pre-eclampsia; EOPE early-onset pre-eclampsia (diagnosed before 34 0/7 weeks of gestation); LOPE late-onset pre-eclampsia (diagnosed at or after 34 0/7 weeks of gestation); BMI body mass index; SGA small for gestational age; DM diabetes mellitus; MAP mean arterial pressure; Uta-PI pulsatility index of the uterine artery; hCG human chorionic gonadotropin; hCG-h hyperglycosylated hCG; %hCG-h the ratio of hCG-h to hCG; PAPP-A pregnancy-associated plasma protein a; PlGF placental growth factor; MoM multiple of the median
  4. Early-onset PE = pre-eclampsia diagnosis < 34 weeks of gestation; Late-onset PE = pre-eclampsia diagnosis ≥ 34 weeks of gestation; Severe pre-eclampsia = systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 110 mmHg and/or proteinuria ≥5 g/24 h, Non-severe pre-eclampsia = PE not fulfilling the criteria of severe pre-eclampsia