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Table 2 Quantitative gut microbiota composition in IAP-treated and untreated infants

From: Adverse events in women and children who have received intrapartum antibiotic prophylaxis treatment: a systematic review

Organism Study Number of infants (n) in each group Log colony forming units per gram (CFU/g)
Day 3 Day 6/7 Day 30 Day 90
Family
Staphylococcaceae Arboleya 2015 [32] IAP n = 14 Control n = 13    Lower log cells/g in IAP, p < 0.05  
Enterobacteriaceae Arboleya 2015 [32] IAP n = 14 Control n = 13    Higher log cells/g in IAP, p < 0.05  
Jaureguy 2004 [39]a IAP n = 25 Control n = 25 IAP: Md 8.4 (R 3.3-9.5) Control: Md 9.2 (R 3.3-9.8) p = 0.18    
Genera
Bacteroides Jaureguy 2004 [39]a IAP n = 25 Control n = 25 IAP: Md 8.0 (R 6.3-10.3) Control: Md 7.9 (R 3.6-9.6) p = 0.12    
Bifidobacteria Jaureguy 2004 [39]a IAP n = 25 Control n = 25 IAP: Md 8.2 (R 4.3-9.5) Control: Md 8.5 (R 6.9-10.3) p = 0.10    
Arboleya 2015 [32] IAP n = 14 Control n = 13     Lower log cells/g in IAP, p < 0.05
Bifidobacterium spp. Aloisio 2014 [30]a IAP n = 26 Control n = 26   IAP: M 5.85 (R 3.24-7.79) Control: M 7.29 (R 4.12-10.95) p = 0.001   
Corvaglia 2016 [36]a IAP n = 35 Control n = 29   IAP: Md 6.01 (IQR 5.51-6.98) Control: Md 7.80 (IQR 6.61-8.26) p = 0.000 IAP: Md 8.41 (IQR 7.71-8.80) Control: Md 8.39 (IQR 7.96-8.86) p = 0.363  
Mazzola 2016 [57]a Breast-fed IAP n = 7 Breast-fed Control n = 7   IAP: Md 5.86 Control: Md 8.16 p = 0.005 IAP: Md 7.72 (compared to day 7, p = 0.035) Control: Md 8.62 NS  
Mixed-fed IAP n = 6 Mixed-fed Control n = 6   IAP: Md 5.81 Control: Md 7.19 p = 0.03 IAP: Md 8.50 (compared to day 7, p = 0.036) Control Md 8.55 (compared to day 7, p = 0.028)  
Clostridia Jaureguy 2004 [39]a IAP n = 25 Control n = 25 IAP: Md 5.3 (R 4.3-5.8) Control: Md 6.2 (R 3.6-8.1) p = 0.01    
Enterococci Jaureguy 2004 [39]a IAP n = 25 Control n = 25 IAP: Md 8.3 (R 3.6-10.3) Control: Md 7.3 (R 3.3-9.5) p = 0.78    
Lactobacillus spp. Aloisio 2014 [30]a IAP n = 26 Control n = 26   IAP: M 6.69 (R 5.40-8.93) Control: M 6.73 (R 5.45-8.20) NS   
Corvaglia 2016 [36]a IAP n = 35 Control n = 29   IAP: Md 5.56 (IQR 4.94-6.14) Control: Md 5.45 (IQR 4.81-6.14) p = 0.872 IAP: Md 5.29 (IQR 4.68–6.01) Control: Md 5.25 (IQR 4.60-6.15) p = 0.932  
Staphylococci Jaureguy 2004 [39]a IAP n = 25 Control n = 25 IAP: Md 6.5 (R 3.6-8.0) Control: Md 7.0 (R 4.0-9.3) p = 0.53    
Species
Escherichia coli Aloisio 2014 [30]a IAP n = 26 Control n = 26   IAP: M 8.18 (R 4.09-12.70) Control: M 9.03 (R 5.61-11.78) NS   
Bacteroides fragilis Aloisio 2014 [30]a IAP n = 26 Control n = 26   IAP: M 8.17 (R 4.68-11.99) Control: M 8.53 (R 5.22-11.16) NS   
Corvaglia 2016 [36]a IAP n = 35 Control n = 29   IAP: Md 7.71 (IQR 5.80-9.33) Control: Md 7.75 (IQR 5.87-9.61) p > 0.05 IAP: Md 7.36 (IQR 5.80-9.09) Control: Md 8.51 (IQR 5.86-9.37) p > 0.05  
Clostridium difficile Aloisio 2014 [30]a IAP n = 26 Control n = 26   IAP: M 3.89 (R 3.12-4.80) Control: M 3.70 (R 2.85-5.46) NS   
Total bacteria Mazzola 2016 [57]a Breast-fed IAP n = 7 Breast-fed Control n = 7 Mixed-fed IAP n = 6 Mixed-fed Control n = 6   All groups: R 9.38-9.71 All groups: R 9.53-9.83  
Arboleya 2015 [32] IAP n = 14 Control n = 13    Higher log cells/g in IAP, p < 0.05  
  1. IAP intrapartum antibiotic prophylaxis, M mean, Md median, R range, IQR interquartile range, p probability value
  2. aGBS prophylaxis