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Table 2 The pregnancy outcomes in the whole cohort of women with type 1 diabetes and evolution over time

From: Risk factors for large-for-gestational age infants in pregnant women with type 1 diabetes

Outcome

1992-2014

1992-1998

1999-2004

2005-2009

2010-2014

P value

(n = 259)

(n = 74)

(n = 64)

(n = 59)

(n = 62)

WOMEN

      

Pregnancy induced hypertension

12.7 % (n = 33)

16.2 % (n = 12)

21.9 % (n = 14)

5.1 % (n = 3)

6.5 % (n = 4)

0.033

Pre-eclampsia

8.1 % (n = 21)

8.1 % (n = 6)

4.7 % (n = 3)

8.5 % (n = 5)

11.3 % (n = 7)

0.55

Preterm delivery

19.7 % (n = 51)

21.6 % (n = 16)

15.6 % (n = 10)

22.0 % (n = 13)

19.4 % (n = 12)

0.83

Caesarean section

67.2 % (n = 174)

68.9 % (n = 51)

73.4 % (n = 47)

59.3 % (n = 35)

66.1 % (n = 41)

0.70

Primary Caesarean section

46.3 % (n = 120)

52.7 % (n = 39)

48.4 % (n = 41)

30.5 % (n = 18)

51.6 % (n = 32)

0.038

FETAL

      

Male

53.7 % (n = 139)

47.3 % (n = 35)

59.4 % (n = 38)

50.8 % (n = 30)

58.1 % (n = 36)

0.48

Gestational age at birth (weeks)

37.0 ± 1.4

36.7 ± 1.5

37.1 ± 1.1

37.2 ± 1.5

37.2 ± 1.4

0.35

Birth weight (g)

3458 ± 605

3454 ± 652

3399 ± 649

3462 ± 596

3518 ± 511

0.57

LGA infant

45.2 % (n = 117)

50.0 % (n = 37)

35.9 % (n = 23)

40.7 % (n = 24)

53.2 % (n = 33)

0.19

Macrosomia

16.2 % (n = 42)

17.6 % (n = 13)

15.6 % (n = 10)

13.6 % (n = 8)

17.7 % (n = 11)

0.92

Admissions NICU

66.3 % (n = 171)

97.3 % (n = 72)

79.7 % (n = 51)

40.7 % (n = 24)

39.3 % (n = 24)

0.001

Neonatal hypoglycaemia

29.0 % (n = 67)

42.6 % (n = 20)

28.6 % (n = 18)

25.4 % (n = 15)

22.6 % (n = 14)

0.18

  1. NICU neonatal intensive care unit, LGA large-for-gestational age infant
  2. Results are given as mean (SD) or % (n); P value in bold indicates a statistically significant difference between the four time periods. Generalized linear mixed models were used for binary variables, and linear mixed models for continuous variables with time period as a factor