Table 1 The characteristics of the whole cohort of type 1 diabetes and evolution over time
From: Risk factors for large-for-gestational age infants in pregnant women with type 1 diabetes
1992-2014 | 1992-1998 | 1999-2004 | 2005-2009 | 2010-2014 | P value | |
|---|---|---|---|---|---|---|
(n = 259) | (n = 74) | (n = 64) | (n = 59) | (n = 62) | ||
Duration of Diabetes | 13.7 ± 7.1 | 11.7 ± 5.8 | 13.7 ± 7.5 | 13.3 ± 6.7 | 15.4 ± 8.9 | 0.002 |
Maternal age at delivery (years) | 29.5 ± 5.2 | 28.7 ± 3.9 | 29.7 ± 3.7 | 29.6 ± 4.2 | 30.4 ± 4.9 | 0.03 |
Weight trimester 1 (kg) | 69.9 ± 10.8 | 67.8 ± 10.0 | 70.0 ± 10.7 | 71.4 ± 10.6 | 70.7 ± 11.9 | 0.003 |
Weight at delivery (kg) | 82.1 ± 11.1 | 78.4 ± 9.6 | 83.4 ± 11.9 | 85.3 ± 11.3 | 82.3 ± 10.7 | 0.001 |
BMI before pregnancy (kg/m2) | 25.3 ± 3.8 | 24.9 ± 3.7 | 25.5 ± 3.8 | 25.3 ± 3.6 | 25.4 ± 4.2 | 0.12 |
Obesity | 10.9 % (n = 28) | 9.6 % (n = 7) | 14.1 % (n = 9) | 6.8 % (n = 4) | 13.1 % (n = 8) | 0.48 |
Overweight | 33.9 % (n = 87) | 23.3 % (n = 17) | 28.1 % (n = 18) | 47.5 % (n = 28) | 39.3 % (n = 24) | 0.009 |
Excessive weight gain | 34.4 % (n = 91) | 21.3 % (n = 15) | 42.2 % (n = 27) | 40.4 % (n = 25) | 37.7 % (n = 24) | 0.019 |
HbA1c before pregnancy mmol/mol (%) | 52 ± 10 | 51 ± 10 | 53 ± 12 | 50 ± 6 | 53 ± 12 | 0.24 |
(6.9 ± 0.9) | (6.8 ± 0.9) | (7.0 ± 1.1) | (6.7 ± 0.6) | (7.0 ± 1.1) | ||
HbA1c trimester 1 mmol/mol (%) | 49 ± 8 | 46 ± 8 | 51 ± 11 | 48 ± 5 | 50 ± 10 | 0.05 |
(6.6 ± 0.8) | (6.4 ± 0.8) | (6.8 ± 1.0) | (6.5 ± 0.5) | (6.7 ± 0.9) | ||
HbA1c trimester 2 | 41 ± 8 | 39 ± 7 | 41 ± 7 | 42 ± 7 | 42 ± 8 | 0.23 |
mmol/mol (%) | (5.9 ± 0.7) | (5.7 ± 0.7) | (5.9 ± 0.6) | (6.0 ± 0.6) | (6.0 ± 0.7) | |
HbA1c trimester 3 | 43 ± 7 | 41 ± 8 | 43 ± 7 | 44 ± 5 | 44 ± 7 | 0.10 |
mmol/mol (%) | (6.1 ± 0.6) | (5.9 ± 0.7) | (6.1 ± 0.6) | (6.2 ± 0.4) | (6.2 ± 0.6) |