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Table 3 Median hormone concentrations (10–90th percentiles) overall and by parity a

From: Hormone concentrations throughout uncomplicated pregnancies: a longitudinal study

  All women (n = 50) Primiparous (n = 25) Multiparous (n = 25) pMW c
Estradiol (ng/mL)
 1st trimester 2.18 (1.16–3.59) 2.11 (1.19–4.00) 2.42 (1.12–3.12) 0.92
 2nd trimester 9.71 (5.33–15.1) 10.3 (5.20–14.8) 9.45 (5.46–15.3) 0.64
 3rd trimester 20.4 (12.8–32.9) 22.3 (13.6–35.6) 19.5 (12.8–31.5) 0.71
Median %-change b 876 % 858 % 889 %  
Estrone (ng/mL)
 1st trimester 0.93 (0.41–1.72) 0.71 (0.35–2.07) 1.11 (0.48–1.60) 0.14
 2nd trimester 4.28 (1.99–8.54) 3.96 (1.64–8.84) 4.56 (2.77–6.88) 0.85
 3rd trimester 11.5 (3.70–18.9) 10.4 (3.65–21.3) 11.7 (3.77–17.8) 0.92
Median %-change b 976 % 919 % 1053 %  
Progesterone (ng/mL)
 1st trimester 25.6 (16.6–40.7) 27.3 (20.0–42.2) 23.0 (13.5–37.8) 0.03
 2nd trimester 48.1 (31.6–78.5) 53.8 (37.8–85.2) 42.1 (28.7–71.3) 0.03
 3rd trimester 130 (72.6–200) 138 (105–215) 107 (60.2–163) 0.007
Median %-change b 411 % 422 % 396 %  
Testosterone (ng/mL)
 1st trimester 0.96 (0.42–1.98) 1.34 (0.78–2.15) 0.66 (0.36–1.11) <0.0001
 2nd trimester 1.19 (0.55–3.35) 1.98 (1.05–3.96) 0.73 (0.44–1.43) <0.0001
 3rd trimester 1.32 (0.50–4.07) 2.56 (0.54–6.06) 0.71 (0.50–2.41) 0.0008
Median %-change b 61 % 74 % 38 %  
Prolactin (ng/mL)
 1st trimester 28.8 (16.3–57.6) 32.6 (19.8–63.3) 27.6 (10.6–47.0) 0.10
 2nd trimester 126 (54.9–206) 105 (49.0–181) 139 (72–206) 0.32
 3rd trimester 216 (124–318) 177 (115–258) 225 (133–320) 0.12
Median %-change b 570 % 449 % 795 %  
OPG (pmol/L)
 1st trimester 3.79 (2.63–5.90) 3.45 (2.71–5.61) 3.93 (2.37–5.99) 0.21
 2nd trimester 5.26 (3.10–7.91) 4.96 (3.28–7.15) 6.01 (3.10–9.01) 0.17
3rd trimester 9.74 (4.44–17.5) 8.18 (4.09–20.3) 10.5 (5.59–16.4) 0.12
Median %-change b 143 % 112 % 162 %  
sRANKL (pmol/L)
 1st trimester 0.43 (0.10–0.81) 0.32 (0.06–0.92) 0.56 (0.31–0.74) 0.04
 2nd trimester 0.43 (0.10–0.91) 0.31 (0.06–1.05) 0.51 (0.27–0.81) 0.26
 3rd trimester 0.43 (0.20–0.82) 0.41 (0.14–0.95) 0.43 (0.30–0.72) 0.35
Median %-change b 8 % 30 % −14 %  
  1. a Conversion from ng/ml to nmol/l (SI units): estradiol*3.671, estrone*3.699, progesterone*3.18, testosterone*3.467, and prolactin*0.04348
  2. b Median %-change between 1st and 3rd trimester
  3. c p-value obtained from the Mann–Whitney-U test comparing primi- and multiparous women