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Table 1 Overview of the eight trials from which patients were selected for an interview

From: Pregnant womens’ concerns when invited to a randomized trial: a qualitative case control study

Trial acronyma

Research question

Treatment arms

Eligible women

Allo [9]

Does antenatal allopurinol administration reduce hypoxic-ischaemic encephalopathy in neonates exposed to intra-uterine asphyxia?

Allopurinol or placebo, antenatal administered to the mother

Women at term in whom the fetus is suspected of intra-uterine asphyxia

Apostel I [10]

Is testing for fibronectin a cost-effective strategy that prevents unnecessary treatment in women with threatened preterm labour?

Tocolytics (nifedipine) or placebo

Patients with symptoms of preterm labour, and a negative fibronectin test and a cervical length between 10–30 mm

Apostel II [11]

Does sustained tocolysis in women with threatened preterm labour reduce neonatal morbidity?

Nifedipine or placebo for 12 days

Women between 24 to 31+6 weeks pregnant who have been treated with tocolysis and steroids for preterm birth for 48 h

CHIPS [12]

Is there a difference on pregnancy loss or NICU admission between less tight and tight control of blood pressure in women with non-severe non-proteinuric pre-existting hypertension or gestational hypertension remote from term?

‘less tight’ dBP control or ‘tight’ dBP control

Women with non-severe non-proteinuric pre-existing hypertension or gestational hypertension remote from term

Hypitat II [15]

What is the effectiveness and efficiency of induction of labour in women with pregnancy induced hypertension or mild preeclampsia with a gestational age of 34–37 weeks of pregnancy, as compared to expectant management under regular monitoring?

Induction of labor or expectant management under regular monitoring

Women with pregnancy induced hypertension or mild preeclampsia with a gestational age of 34–37 weeks of gestation

Ppromexil [14]

What is the effectiveness and cost-effectiveness of induction of labor after PPROM between 34 and 37 weeks gestation compared to expectant monitoring.

Induction of labor or expectant monitoring

Pregnant women with preterm premature rupture of membranes between 34 + 0/7 weeks to 37 weeks of gestation

ProTWIN [16]

Is prophylactic use of a cervical pessary effective in the prevention of preterm delivery and the neonatal mortality and morbidity resulting from preterm delivery in multiple pregnancy?

Pessary or no treatment

All women presenting with a multiple pregnancy between 12–20 weeks of gestation

WOMB [13]

What is the effect of RBC transfusion on health related quality of life?

RBC transfusion or no intervention

Women with PPH or a decrease in Hb, 12 to 24 h after delivery or caesarean section.

  1. aMore information about these studies can be found at: www.studies-obsgyn.nl