From: Pregnant womens’ concerns when invited to a randomized trial: a qualitative case control study
Trial acronyma | Research question | Treatment arms | Eligible women |
---|---|---|---|
Allo [9] | Does antenatal allopurinol administration reduce hypoxic-ischaemic encephalopathy in neonates exposed to intra-uterine asphyxia? | Allopurinol or placebo, antenatal administered to the mother | Women at term in whom the fetus is suspected of intra-uterine asphyxia |
Apostel I [10] | Is testing for fibronectin a cost-effective strategy that prevents unnecessary treatment in women with threatened preterm labour? | Tocolytics (nifedipine) or placebo | Patients with symptoms of preterm labour, and a negative fibronectin test and a cervical length between 10–30 mm |
Apostel II [11] | Does sustained tocolysis in women with threatened preterm labour reduce neonatal morbidity? | Nifedipine or placebo for 12 days | Women between 24 to 31+6 weeks pregnant who have been treated with tocolysis and steroids for preterm birth for 48 h |
CHIPS [12] | Is there a difference on pregnancy loss or NICU admission between less tight and tight control of blood pressure in women with non-severe non-proteinuric pre-existting hypertension or gestational hypertension remote from term? | ‘less tight’ dBP control or ‘tight’ dBP control | Women with non-severe non-proteinuric pre-existing hypertension or gestational hypertension remote from term |
Hypitat II [15] | What is the effectiveness and efficiency of induction of labour in women with pregnancy induced hypertension or mild preeclampsia with a gestational age of 34–37 weeks of pregnancy, as compared to expectant management under regular monitoring? | Induction of labor or expectant management under regular monitoring | Women with pregnancy induced hypertension or mild preeclampsia with a gestational age of 34–37 weeks of gestation |
Ppromexil [14] | What is the effectiveness and cost-effectiveness of induction of labor after PPROM between 34 and 37 weeks gestation compared to expectant monitoring. | Induction of labor or expectant monitoring | Pregnant women with preterm premature rupture of membranes between 34 + 0/7 weeks to 37 weeks of gestation |
ProTWIN [16] | Is prophylactic use of a cervical pessary effective in the prevention of preterm delivery and the neonatal mortality and morbidity resulting from preterm delivery in multiple pregnancy? | Pessary or no treatment | All women presenting with a multiple pregnancy between 12–20 weeks of gestation |
WOMB [13] | What is the effect of RBC transfusion on health related quality of life? | RBC transfusion or no intervention | Women with PPH or a decrease in Hb, 12 to 24 h after delivery or caesarean section. |