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Table 2 Published studies comparing oxytocin (syntocinon) with alternative uterotonic agents

From: Study Protocol. ECSSIT – Elective Caesarean Section Syntocinon® Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon®) 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss at elective caesarean section

Author, citation Study design Exposures Outcome measures Results Conclusions
Catanzarite VA et al
Am J Perinatol
1990;7:39–42.
RCT double blind
46 women
Elective CS
Oxytocin 20 IU iv bs PGF125 mcg im
After placenta delivered
ΔHCT (EBL) No difference in EBL No benefit with carboprost
Chou MM et al
Am J Obstet Gynecol
1994;171:1356–60.
RCT double blind
60 women
Elective CS
Oxytocin 20 IU iv vs PGF125 mcg im EBL
ΔHCT, ΔHb
Side effects (SE)
No significant differences No benefit with carboprost
Boucher M et al
J Perinatol
1998;18:202–7.
RCT double blind
57 women
Elective CS
Oxytocin infusion
16 hr vs
Carbetocin 100 mcg iv
EBL
Side effects
Carbetocin as effective
Lower EBL
Carbetocin as effective/reliable
Dansereau J et al
Am J Obstet Gynecol
1999;180:670–6.
RCT double blind
635 women
Elective CS
Oxytocin infusion
8 hr vs
Carbetocin 100 mcg iv
Need for additional uterotonic agent Carbetocin more effective
10% vs 4.7%
Carbetocin more effective than infusion only
Acharya G et al
Acta Obst Gyn Scand
2001;80:245–50.
RCT single blind
60 women
Elective CS/regional
Oxytocin 10 IU iv vs
Misoprostol 400 mcg po
EBL, HCT, Hb,
Side effects
No difference
No SE
Misoprostol as safe/effective as 10 IU oxytocin
Lokugamage AU et al
Aus NZ J Obst Gyne
2001;41:411–4.
RCT double blind
40 women
Elective/Em CS
Oxytocin 10 IU iv vs
Misoprostol 400 mcg po
EBL
ΔHb
Additional uterotonic
No difference Misoprostol an alternative to 10 IU
Need for large RCT