Table 2 Published studies comparing oxytocin (syntocinon) with alternative uterotonic agents
Author, citation | Study design | Exposures | Outcome measures | Results | Conclusions |
|---|---|---|---|---|---|
Catanzarite VA et al Am J Perinatol 1990;7:39–42. | RCT double blind 46 women Elective CS | Oxytocin 20 IU iv bs PGF2α125 mcg im After placenta delivered | ΔHCT (EBL) | No difference in EBL | No benefit with carboprost |
Chou MM et al Am J Obstet Gynecol 1994;171:1356–60. | RCT double blind 60 women Elective CS | Oxytocin 20 IU iv vs PGF2α125 mcg im | EBL ΔHCT, ΔHb Side effects (SE) | No significant differences | No benefit with carboprost |
Boucher M et al J Perinatol 1998;18:202–7. | RCT double blind 57 women Elective CS | Oxytocin infusion 16 hr vs Carbetocin 100 mcg iv | EBL Side effects | Carbetocin as effective Lower EBL | Carbetocin as effective/reliable |
Dansereau J et al Am J Obstet Gynecol 1999;180:670–6. | RCT double blind 635 women Elective CS | Oxytocin infusion 8 hr vs Carbetocin 100 mcg iv | Need for additional uterotonic agent | Carbetocin more effective 10% vs 4.7% | Carbetocin more effective than infusion only |
Acharya G et al Acta Obst Gyn Scand 2001;80:245–50. | RCT single blind 60 women Elective CS/regional | Oxytocin 10 IU iv vs Misoprostol 400 mcg po | EBL, HCT, Hb, Side effects | No difference No SE | Misoprostol as safe/effective as 10 IU oxytocin |
Lokugamage AU et al Aus NZ J Obst Gyne 2001;41:411–4. | RCT double blind 40 women Elective/Em CS | Oxytocin 10 IU iv vs Misoprostol 400 mcg po | EBL ΔHb Additional uterotonic | No difference | Misoprostol an alternative to 10 IU Need for large RCT |