Mortality or major morbidity in control group | Mortality or major morbidity in IVIG group | Relative risk reduction | Total sample size required to detect difference with 95% confidence | |
---|---|---|---|---|
 |  |  | 80% power | 90% power |
30% | 26% | 13% | 4,052 | 5,392 |
30% | 25% | 17% | 2,580 | 3,428 |
30% | 20% | 33% | 626 | 824 |
25% | 21% | 16% | 3,572 | 4,748 |
25% | 20% | 20% | 2,266 | 3,006 |
25% | 15% | 40% | 540 | 708 |
20% | 16% | 20% | 2,994 | 3,972 |
20% | 15% | 25% | 1,890 | 2,502 |
20% | 12.5% | 37.5% | 810 | 1,066 |
15% | 12% | 20% | 4,204 | 5,582 |
15% | 10% | 33% | 1,450 | 1,914 |
12% | 9% | 25% | 3,408 | 4,516 |
10% | 7.5% | 25% | 4,166 | 5,524 |