Functional genomics of the pregnant uterus: from expectations to reality, a compilation of studies in the myometrium

Table 2 The main KEGG metabolic pathways, regulatory pathways or molecular complexes expressed in the myometrium

KEGG pathways¹	NP-TNIL	PTNIL-TNIL	TNIL-TIL
Actin cytoskeleton	15	6	0
Focal adhesion	18	6	3
Adherens junctions	11	3	0
Tight junctions	10	0	0
Cytokines-cytokine receptors	8	12	5
Toll-like receptors	5	6	1
TGF-beta signaling	6	2	3
Wnt signaling	7	2	1
MAPK signaling	15	12	4
Phosphatidylinositol signaling	5	8	0
JAK/STAT signaling	6	7	1
Apoptosis	0	6	0
Calcium signaling	8	8	0
Neuroactive ligand-receptors	6	6	0

¹A detailed description of KEGG pathways is accessible at [25]. For each pathway, gene transcripts showed at least a 2 fold or more, up or down-regulation after paired comparisons of the following stages: non-pregnant (NP) versus term not in labor myometrium (TNIL), preterm (PTNIL) versus TNIL myometrium, or TNIL versus term in labor myometrium (TIL). Number of genes represented in a defined pathway. A total of 118 differentially expressed genes (genes may belong to several pathways) were detected, 0: no gene represented for the corresponding pathway.

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