Table 1 Summary of barusiban and atosiban PK/PD characteristics
From: Barusiban suppresses oxytocin-induced preterm labour in non-human primates
Pharmacodynamics (PD) | Barusiban | Atosiban |
|---|---|---|
Onset of action, hours | ≤0.5–1.5 | ≤0.5–1.0 |
Efficacy (decrease in IUP), % | ≤98 | ≤96 |
Duration of action, hours | > 13–15 | 1–3 |
Potency (IC50), ng/ml | 12.7 | 47.4 |
Pharmacokinetics (PK) | Barusiban | Atosiban |
Half-life, hours | 1.46–2.57 | 0.46–0.66 |
Clearance, ml h-1 kg-1 | 25–66 | 539–936 |
Distribution, ml kg-1 | 70–159 | 359–640 |